About   Help   FAQ
Neurod1 Gene Detail
Summary
  • Symbol
    Neurod1
  • Name
    neurogenic differentiation 1
  • Synonyms
    BETA2, bHLHa3, Nd1, Neurod
  • Feature Type
    protein coding gene
  • IDs
    MGI:1339708
    NCBI Gene: 18012
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:79282981-79286980 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 47.58 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    83 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1339708
 protein coding gene Chr2:79282865-79287095 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025878
 protein coding gene Chr2:80000694-80004926 (-)
A/J MGP_AJ_G0025855
 protein coding gene Chr2:76911591-76915820 (-)
AKR/J MGP_AKRJ_G0025824
 protein coding gene Chr2:78915267-78919497 (-)
BALB/cJ MGP_BALBcJ_G0025851
 protein coding gene Chr2:77033379-77037608 (-)
C3H/HeJ MGP_C3HHeJ_G0025610
 protein coding gene Chr2:79143923-79148152 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026297
 protein coding gene Chr2:82373609-82377839 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023700
 protein coding gene Chr2:74156948-74161185 (-)
CAST/EiJ MGP_CASTEiJ_G0025072
 protein coding gene Chr2:79565690-79569921 (-)
CBA/J MGP_CBAJ_G0025591
 protein coding gene Chr2:85337665-85341894 (-)
DBA/2J MGP_DBA2J_G0025722
 protein coding gene Chr2:76456472-76464180 (-)
FVB/NJ MGP_FVBNJ_G0025684
 protein coding gene Chr2:75827847-75832078 (-)
LP/J MGP_LPJ_G0025810
 protein coding gene Chr2:79850946-79855175 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025715
 protein coding gene Chr2:87171618-87176247 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026353
 protein coding gene Chr2:79089095-79093326 (-)
PWK/PhJ MGP_PWKPhJ_G0024815
 protein coding gene Chr2:76403816-76408080 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024621
 protein coding gene Chr2:79350771-79354995 (-)
WSB/EiJ MGP_WSBEiJ_G0025141
 protein coding gene Chr2:79719576-79723806 (-)



Homology
more
  • Human Ortholog
    NEUROD1, neuronal differentiation 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NEUROD1, neuronal differentiation 1
  • Synonyms
    BETA2, BHF-1, bHLHa3, MODY6, NEUROD, T2D
  • Links
    NCBI Gene ID: 4760
    neXtProt AC: NX_Q13562
    UniProt: Q13562

  • Chr Location
    2q31.3; chr2:181668295-181680827 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Neurod1 mouse models; 5 with human NEUROD1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    68 phenotypes from 6 alleles in 10 genetic backgrounds
    37 phenotypes from multigenic genotypes
    62 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit neonatal diabetes, pancreatic enteroendocrine cell deficits, impaired hearing and balance, retinal degeneration, and seizures. Survival past birth is dependent on genetic background.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    84
  • GO References
    28
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1856
  • Tissues
    451
  • cDNA Data
    48
  • Literature Summary
    455
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18012 NCBI Gene Model | MGI Sequence Detail 4000 C57BL/6J ±  kb
    transcript NM_010894 RefSeq | MGI Sequence Detail 2510 ZRU/MplStud  
    polypeptide Q60867 UniProt | EBI | MGI Sequence Detail 357 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000011152 neurogenic differentiation factor 1
      (term hierarchy)
    • PDB
      2QL2
    • InterPro Domains
      IPR050359 Basic helix-loop-helix transcription factors
      IPR036638 Helix-loop-helix DNA-binding domain superfamily
      IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
      IPR022575 Neurogenic differentiation factor, domain of unknown function
      IPR016637 Neurogenic differentiation factor NeuroD
    • GlyGen
      Q60867 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 107
      Genomic 1
      cDNA 53
      Primer pair 21
      Other 32

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-26011, MGI:104577
    References
    more
    • Summaries
      All 561
      Developmental Gene Expression 455
      Diseases 1
      Gene Ontology 28
      Phenotypes 62
    • Earliest
      J:25296 Lee JE, et al., Conversion of Xenopus ectoderm into neurons by NeuroD, a basic helix-loop-helix protein. Science. 1995 May 12;268(5212):836-44
    • Latest
      J:354849 Wutikeli H, et al., Role of Elavl-like RNA-binding protein in retinal development and signal transduction. Biochim Biophys Acta Mol Basis Dis. 2024 Sep 20;1871(1):167518
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory