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P2rx7 Gene Detail
Summary
  • Symbol
    P2rx7
  • Name
    purinergic receptor P2X, ligand-gated ion channel, 7
  • Synonyms
    P2X(7), P2X7R, P2X7 receptor
  • Feature Type
    protein coding gene
  • IDs
    MGI:1339957
    NCBI Gene: 18439
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:122781974-122829495 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 62.50 cM, cytoband F
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1644 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1339957
 protein coding gene Chr5:122781974-122830399 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030055
 protein coding gene Chr5:126288598-126337736 (+)
A/J MGP_AJ_G0030020
 protein coding gene Chr5:121055250-121102671 (+)
AKR/J MGP_AKRJ_G0029956
 protein coding gene Chr5:124950938-125007491 (+)
BALB/cJ MGP_BALBcJ_G0030031
 protein coding gene Chr5:122403411-122451047 (+)
C3H/HeJ MGP_C3HHeJ_G0029748
 protein coding gene Chr5:125582236-125632662 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030484
 protein coding gene Chr5:131155961-131203500 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027710
 protein coding gene Chr5:115659935-115707659 (+)
CAST/EiJ MGP_CASTEiJ_G0029157
 protein coding gene Chr5:124675806-124717717 (+)
CBA/J MGP_CBAJ_G0029718
 protein coding gene Chr5:136282112-136335176 (+)
DBA/2J MGP_DBA2J_G0029868
 protein coding gene Chr5:121111174-121159625 (+)
FVB/NJ MGP_FVBNJ_G0029824
 protein coding gene Chr5:120105503-120160123 (+)
LP/J MGP_LPJ_G0029957
 protein coding gene Chr5:126825843-126872975 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029855
 protein coding gene Chr5:140013081-140062147 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030525
 protein coding gene Chr5:124554753-124604266 (+)
PWK/PhJ MGP_PWKPhJ_G0028871
 protein coding gene Chr5:119895737-119943526 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028708
 protein coding gene Chr5:122268416-122317580 (+)
WSB/EiJ MGP_WSBEiJ_G0029232
 protein coding gene Chr5:125213546-125264903 (+)



Homology
more
  • Human Ortholog
    P2RX7, purinergic receptor P2X 7
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    P2RX7, purinergic receptor P2X 7
  • Synonyms
    P2X7
  • Links
    NCBI Gene ID: 5027
    neXtProt AC: NX_Q99572
    UniProt: Q99572

  • Chr Location
    12q24.31; chr12:121132819-121188032 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 6 alleles in 11 genetic backgrounds
    10 phenotypes from multigenic genotypes
    343 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene are fertile and viable with no obvious phenotypic abnormality. Cellular responses of macrophages to extracellular ATP are frequently normal however. In addition, long bones are thinner than normal in adult mice.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    198
  • GO References
    46
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    723
  • Tissues
    11
  • cDNA Data
    30
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029468 Ensembl Gene Model | MGI Sequence Detail 47522 C57BL/6J ±  kb
    transcript ENSMUST00000100737 Ensembl | MGI Sequence Detail 4936 Not Applicable  
    polypeptide ENSMUSP00000098303 Ensembl | MGI Sequence Detail 595 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 33
      cDNA 31
      Primer pair 2

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2140909
    References
    more
    • Summaries
      All 460
      Developmental Gene Expression 6
      Gene Ontology 46
      Phenotypes 343
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:357726 Li C, et al., The eATP/P2x7R Axis Drives Quantum Dot-Nanoparticle Induced Neutrophil Recruitment in the Pulmonary Microcirculation. Adv Sci (Weinh). 2024 Oct 4;:e2404661
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory