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Fcna Gene Detail
Summary
  • Symbol
    Fcna
  • Name
    ficolin A
  • Synonyms
    Fcn1, ficolin A
  • Feature Type
    protein coding gene
  • IDs
    MGI:1340905
    NCBI Gene: 14133
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:25514678-25518042 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 17.58 cM, cytoband A3
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    176 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1340905
 protein coding gene Chr2:25514677-25525448 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025461
 protein coding gene Chr2:23538088-23541452 (-)
A/J MGP_AJ_G0025438
 protein coding gene Chr2:22617140-22620503 (-)
AKR/J MGP_AKRJ_G0025408
 protein coding gene Chr2:23381677-23385040 (-)
BALB/cJ MGP_BALBcJ_G0025434
 protein coding gene Chr2:22735076-22738442 (-)
C3H/HeJ MGP_C3HHeJ_G0025195
 protein coding gene Chr2:23314365-23317729 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025878
 protein coding gene Chr2:24275016-24278380 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023289
 protein coding gene Chr2:21523417-21526818 (-)
CAST/EiJ MGP_CASTEiJ_G0024658
 protein coding gene Chr2:23180671-23185622 (-)
CBA/J MGP_CBAJ_G0025173
 protein coding gene Chr2:25115115-25118479 (-)
DBA/2J MGP_DBA2J_G0025306
 protein coding gene Chr2:22461597-22464960 (-)
FVB/NJ MGP_FVBNJ_G0025268
 protein coding gene Chr2:22208201-22211565 (-)
LP/J MGP_LPJ_G0025392
 protein coding gene Chr2:23467228-23470592 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025299
 protein coding gene Chr2:25303438-25306801 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025937
 protein coding gene Chr2:23337927-23341290 (-)
PWK/PhJ MGP_PWKPhJ_G0024406
 protein coding gene Chr2:22275820-22279159 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024206
 protein coding gene Chr2:23466489-23469872 (-)
WSB/EiJ MGP_WSBEiJ_G0024727
 protein coding gene Chr2:23397580-23400942 (-)



Homology
less
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 2 genetic backgrounds
    4 phenotypes from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit normal collagen antibody-induced arthritis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    743
  • Tissues
    22
  • cDNA Data
    43
  • Literature Summary
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000026938 Ensembl Gene Model | MGI Sequence Detail 3365 C57BL/6J ±  kb
transcript ENSMUST00000028307 Ensembl | MGI Sequence Detail 1374 Not Applicable  
polypeptide ENSMUSP00000028307 Ensembl | MGI Sequence Detail 334 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 45
    cDNA 43
    Primer pair 1
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:1270842
References
more
  • Summaries
    All 40
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 11
  • Earliest
    J:46796 Fujimori Y, et al., Molecular cloning and characterization of mouse ficolin-A. Biochem Biophys Res Commun. 1998 Mar 27;244(3):796-800
  • Latest
    J:348350 Zhu LW, et al., Ficolin-A induces macrophage polarization to a novel pro-inflammatory phenotype distinct from classical M1. Cell Commun Signal. 2024 May 15;22(1):271
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory