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Akap3 Gene Detail
Summary
  • Symbol
    Akap3
  • Name
    A kinase anchor protein 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341149
    NCBI Gene: 11642
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:126830061-126851271 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 61.92 cM
Strain
Comparison
more
  • SNPs within 2kb
    525 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1341149
 protein coding gene Chr6:126830061-126851271 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031306
 protein coding gene Chr6:130330932-130352078 (+)
A/J MGP_AJ_G0031277
 protein coding gene Chr6:125364054-125386893 (+)
AKR/J MGP_AKRJ_G0031205
 protein coding gene Chr6:128761864-128782984 (+)
BALB/cJ MGP_BALBcJ_G0031284
 protein coding gene Chr6:124939471-124961262 (+)
C3H/HeJ MGP_C3HHeJ_G0031008
 protein coding gene Chr6:128885571-128908155 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031741
 protein coding gene Chr6:133729345-133750468 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028889
 protein coding gene Chr6:122551068-122572284 (+)
CAST/EiJ MGP_CASTEiJ_G0030389
 protein coding gene Chr6:129085389-129106535 (+)
CBA/J MGP_CBAJ_G0030969
 protein coding gene Chr6:138860719-138881832 (+)
DBA/2J MGP_DBA2J_G0031125
 protein coding gene Chr6:124264460-124285833 (+)
FVB/NJ MGP_FVBNJ_G0031074
 protein coding gene Chr6:123194270-123216025 (+)
LP/J MGP_LPJ_G0031205
 protein coding gene Chr6:130440607-130465157 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031113
 protein coding gene Chr6:142832493-142855261 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031776
 protein coding gene Chr6:128716606-128738971 (+)
PWK/PhJ MGP_PWKPhJ_G0030104
 protein coding gene Chr6:122527471-122549504 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029933
 protein coding gene Chr6:126792089-126815524 (+)
WSB/EiJ MGP_WSBEiJ_G0030474
 protein coding gene Chr6:129085417-129106606 (+)



Homology
more
  • Human Ortholog
    AKAP3, A-kinase anchoring protein 3
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AKAP3, A-kinase anchoring protein 3
  • Synonyms
    AKAP 110, AKAP110, CT82, FSP95, HEL159, PRKA3, SOB1, SPGF82
  • Links
    NCBI Gene ID: 10566
    neXtProt AC: NX_O75969
    UniProt: O75969

  • Chr Location
    12p13.32; chr12:4615508-4649051 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human AKAP3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit male infertility associated with decreased hyperactivated sperm motility and abnormal sperm flagellum.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    731
  • Tissues
    8
  • cDNA Data
    13
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11642 NCBI Gene Model | MGI Sequence Detail 21211 C57BL/6J ±  kb
    transcript NM_009650 RefSeq | MGI Sequence Detail 3173 Not Specified  
    polypeptide O88987 UniProt | EBI | MGI Sequence Detail 864 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 13
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 4
      Gene Ontology 12
      Phenotypes 5
    • Earliest
      J:54430 Vijayaraghavan S, et al., Isolation and molecular characterization of AKAP110, a novel, sperm-specific protein kinase A-anchoring protein. Mol Endocrinol. 1999 May;13(5):705-17
    • Latest
      J:345053 Wang Y, et al., Coiled-coil domain-containing 38 is required for acrosome biogenesis and fibrous sheath assembly in mice. J Genet Genomics. 2023 Sep 13;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory