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Pwp2 Gene Detail
Summary
  • Symbol
    Pwp2
  • Name
    PWP2 periodic tryptophan protein homolog (yeast)
  • Synonyms
    6530411D08Rik, Pwp2, Pwp2h
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341200
    NCBI Gene: 110816
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:78006743-78020983 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 39.72 cM, cytoband C1
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    402 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1341200
 protein coding gene Chr10:78006743-78021005 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017418
 protein coding gene Chr10:78605821-78620068 (-)
A/J MGP_AJ_G0017396
 protein coding gene Chr10:75870658-75884894 (-)
AKR/J MGP_AKRJ_G0017359
 protein coding gene Chr10:77905074-77919309 (-)
BALB/cJ MGP_BALBcJ_G0017358
 protein coding gene Chr10:76038972-76053215 (-)
C3H/HeJ MGP_C3HHeJ_G0017181
 protein coding gene Chr10:78009877-78024114 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017814
 protein coding gene Chr10:81384843-81399076 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015505
 protein coding gene Chr10:72207014-72221335 (-)
CAST/EiJ MGP_CASTEiJ_G0016751
 protein coding gene Chr10:78313953-78328196 (-)
CBA/J MGP_CBAJ_G0017153
 protein coding gene Chr10:84492200-84506443 (-)
DBA/2J MGP_DBA2J_G0017261
 protein coding gene Chr10:75113663-75127908 (-)
FVB/NJ MGP_FVBNJ_G0017253
 protein coding gene Chr10:74290905-74305148 (-)
LP/J MGP_LPJ_G0017332
 protein coding gene Chr10:79047426-79061669 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017280
 protein coding gene Chr10:86469986-86484222 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017856
 protein coding gene Chr10:77950327-77964590 (-)
PWK/PhJ MGP_PWKPhJ_G0016533
 protein coding gene Chr10:74991617-75005864 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016318
 protein coding gene Chr10:77166739-77180995 (-)
WSB/EiJ MGP_WSBEiJ_G0016811
 protein coding gene Chr10:77935565-77949817 (-)



Homology
more
  • Human Ortholog
    PWP2, PWP2 small subunit processome component
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PWP2, PWP2 small subunit processome component
  • Synonyms
    EHOC-17, PWP2H, UTP1
  • Links
    NCBI Gene ID: 5822
    neXtProt AC: NX_Q15269
    UniProt: Q15269

  • Chr Location
    21q22.3; chr21:44107373-44131181 (+)  GRCh38
Human Diseases
less
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    35 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    818
  • Tissues
    64
  • cDNA Data
    81
  • Literature Summary
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032834 Ensembl Gene Model | MGI Sequence Detail 14241 C57BL/6J ±  kb
transcript ENSMUST00000042556 Ensembl | MGI Sequence Detail 3872 Not Applicable  
polypeptide ENSMUSP00000045812 Ensembl | MGI Sequence Detail 919 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    5 Sequences
  • InterPro Domains
    IPR020472 G-protein beta WD-40 repeat
    IPR027145 Periodic tryptophan protein 2
    IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily
    IPR007148 Small-subunit processome, Utp12
    IPR001680 WD40 repeat
    IPR019775 WD40 repeat, conserved site
    IPR036322 WD40-repeat-containing domain superfamily
    IPR015943 WD40/YVTN repeat-like-containing domain superfamily
  • GlyGen
    Q8BU03 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 91
    Genomic 7
    cDNA 81
    Primer pair 1
    Other 2

    Microarray probesets 2
Other
Accession IDs
less
MGI:1923486
References
more
  • Summaries
    All 62
    Developmental Gene Expression 2
    Diseases 2
    Gene Ontology 4
    Phenotypes 35
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:351211 Wu Y, et al., Cathepsin B abundance, activity and microglial localisation in Alzheimer's disease-Down syndrome and early onset Alzheimer's disease; the role of elevated cystatin B. Acta Neuropathol Commun. 2023 Aug 14;11(1):132
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory