About   Help   FAQ
Mark3 Gene Detail
Summary
  • Symbol
    Mark3
  • Name
    MAP/microtubule affinity regulating kinase 3
  • Synonyms
    1600015G02Rik, A430080F22Rik, C-TAK1, ETK-1, mKIAA1860
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341865
    NCBI Gene: 17169
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:111540957-111622655 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 61.05 cM, cytoband F2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1689 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1341865
 protein coding gene Chr12:111540929-111622661 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020136
 protein coding gene Chr12:113973576-114056119 (+)
A/J MGP_AJ_G0020092
 protein coding gene Chr12:109589710-109678683 (+)
AKR/J MGP_AKRJ_G0020067
 protein coding gene Chr12:112727626-112814639 (+)
BALB/cJ MGP_BALBcJ_G0020077
 protein coding gene Chr12:110018074-110102171 (+)
C3H/HeJ MGP_C3HHeJ_G0019879
 protein coding gene Chr12:113229409-113315993 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020522
 protein coding gene Chr12:117508930-117598668 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018135
 protein coding gene Chr12:106031084-106120832 (+)
CAST/EiJ MGP_CASTEiJ_G0019420
 protein coding gene Chr12:108069607-108154982 (+)
CBA/J MGP_CBAJ_G0019846
 protein coding gene Chr12:121977517-122068594 (+)
DBA/2J MGP_DBA2J_G0019963
 protein coding gene Chr12:109070722-109154021 (+)
FVB/NJ MGP_FVBNJ_G0019948
 protein coding gene Chr12:107871075-107954909 (+)
LP/J MGP_LPJ_G0020038
 protein coding gene Chr12:113795739-113883187 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019986
 protein coding gene Chr12:125106846-125195145 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020551
 protein coding gene Chr12:112242018-112336047 (+)
PWK/PhJ MGP_PWKPhJ_G0019181
 protein coding gene Chr12:103712075-103795277 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018984
 protein coding gene Chr12:106406052-106503581 (+)
WSB/EiJ MGP_WSBEiJ_G0019479
 protein coding gene Chr12:113159343-113246919 (+)



Homology
more
  • Human Ortholog
    MARK3, microtubule affinity regulating kinase 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MARK3, microtubule affinity regulating kinase 3
  • Synonyms
    CTAK1, KP78, Par-1a, PAR1A, VIPB
  • Links
    NCBI Gene ID: 4140
    neXtProt AC: NX_P27448
    UniProt: P27448

  • Chr Location
    14q32.32-q32.33; chr14:103385377-103503831 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human MARK3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 1 allele in 1 genetic background
    3 phenotypes from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous disruption of this gene results in decreased body weight, increased energy expenditure, reduced adiposity, and protection from high-fat diet induced obesity. On a high-fat diet, mice show resistance to hepatic steatosis, improved glucose tolerance, and decreased insulin levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    52
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    726
  • Tissues
    17
  • cDNA Data
    16
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000007411 Ensembl Gene Model | MGI Sequence Detail 81699 C57BL/6J ±  kb
    transcript ENSMUST00000221753 Ensembl | MGI Sequence Detail 2394 Not Applicable  
    polypeptide ENSMUSP00000152727 Ensembl | MGI Sequence Detail 797 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 19
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1913749, MGI:2441800
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 7
      Gene Ontology 9
      Phenotypes 17
    • Earliest
      J:31015 Hanks SK, et al., The protein kinase family: conserved features and deduced phylogeny of the catalytic domains. Science. 1988 Jul 1;241(4861):42-52
    • Latest
      J:305797 Zhang Q, et al., Genomic variants within chromosome 14q32.32 regulate bone mass through MARK3 signaling in osteoblasts. J Clin Invest. 2021 Apr 1;131(7)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory