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B4galnt2 Gene Detail
Summary
  • Symbol
    B4galnt2
  • Name
    beta-1,4-N-acetyl-galactosaminyl transferase 2
  • Synonyms
    Dlb-1, Dlb1, Galgt2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1342058
    NCBI Gene: 14422
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:95756769-95805717 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 59.02 cM
  • Mapping Data
    16 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1453 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1342058
 protein coding gene Chr11:95754385-95805786 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018992
 protein coding gene Chr11:98108738-98157412 (-)
A/J MGP_AJ_G0018960
 protein coding gene Chr11:94135531-94191874 (-)
AKR/J MGP_AKRJ_G0018930
 protein coding gene Chr11:97038564-97089612 (-)
BALB/cJ MGP_BALBcJ_G0018933
 protein coding gene Chr11:94617607-94671841 (-)
C3H/HeJ MGP_C3HHeJ_G0018747
 protein coding gene Chr11:97169811-97224159 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019385
 protein coding gene Chr11:101181421-101236609 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017015
 protein coding gene Chr11:91610929-91670143 (-)
CAST/EiJ MGP_CASTEiJ_G0018301
 protein coding gene Chr11:97989709-98041538 (-)
CBA/J MGP_CBAJ_G0018718
 protein coding gene Chr11:105322437-105383936 (-)
DBA/2J MGP_DBA2J_G0018826
 protein coding gene Chr11:93711644-93760845 (-)
FVB/NJ MGP_FVBNJ_G0018815
 protein coding gene Chr11:93183874-93236204 (-)
LP/J MGP_LPJ_G0018896
 protein coding gene Chr11:98674678-98727019 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018842
 protein coding gene Chr11:105340081-105395216 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019425
 protein coding gene Chr11:97328831-97386221 (-)
PWK/PhJ MGP_PWKPhJ_G0018072
 protein coding gene Chr11:94648145-94678767 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017861
 protein coding gene Chr11:97024772-97081194 (-)
WSB/EiJ MGP_WSBEiJ_G0018350
 protein coding gene Chr11:97241185-97302850 (-)



Homology
more
  • Human Ortholog
    B4GALNT2, beta-1,4-N-acetyl-galactosaminyltransferase 2 (SID blood group)
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    B4GALNT2, beta-1,4-N-acetyl-galactosaminyltransferase 2 (SID blood group)
  • Synonyms
    B4GALT, GALGT2
  • Links
    NCBI Gene ID: 124872
    neXtProt AC: NX_Q8NHY0
    UniProt: Q8NHY0

  • Chr Location
    17q21.32; chr17:49120344-49176840 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele show increased startle reflex, increased systemic arterial diastolic blood pressure, abnormal B cell number, increased neutrophil cell number, and increased circulating alkaline phosphatase level.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    726
  • Tissues
    3
  • cDNA Data
    19
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000013418 Ensembl Gene Model | MGI Sequence Detail 48949 C57BL/6J ±  kb
    transcript ENSMUST00000038343 Ensembl | MGI Sequence Detail 1722 Not Applicable  
    polypeptide ENSMUSP00000037239 Ensembl | MGI Sequence Detail 510 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 27
      Genomic 7
      cDNA 19
      Primer pair 1

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-8854, MGD-MRK-8855, MGI:2144234, MGI:895015, MGI:94899
    References
    more
    • Summaries
      All 78
      Developmental Gene Expression 2
      Gene Ontology 10
      Phenotypes 26
    • Earliest
      J:7986 Ponder BA, et al., An allelic difference determines reciprocal patterns of expression of binding sites for Dolichos biflorus lectin in inbred strains of mice. J Embryol Exp Morphol. 1985 Jun;87(1):229-39
    • Latest
      J:343833 Mamsa H, et al., Sarcospan increases laminin-binding capacity of alpha-dystroglycan to ameliorate DMD independent of Galgt2. Hum Mol Genet. 2022 Mar 3;31(5):718-732
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory