About   Help   FAQ
Slc34a2 Gene Detail
Summary
  • Symbol
    Slc34a2
  • Name
    solute carrier family 34 (sodium phosphate), member 2
  • Synonyms
    D5Ertd227e, NaPi-2b, Npt2b, type IIb Na/Picotransporter
  • Feature Type
    protein coding gene
  • IDs
    MGI:1342284
    NCBI Gene: 20531
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:53206695-53229006 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 28.92 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    593 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1342284
 protein coding gene Chr5:53195423-53229006 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029551
 protein coding gene Chr5:52051113-52085769 (+)
A/J MGP_AJ_G0029519
 protein coding gene Chr5:50225892-50260428 (+)
AKR/J MGP_AKRJ_G0029467
 protein coding gene Chr5:51949587-51984255 (+)
BALB/cJ MGP_BALBcJ_G0029528
 protein coding gene Chr5:50713582-50747428 (+)
C3H/HeJ MGP_C3HHeJ_G0029251
 protein coding gene Chr5:52087406-52121216 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029982
 protein coding gene Chr5:54212217-54246376 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027222
 protein coding gene Chr5:46980861-47013544 (+)
CAST/EiJ MGP_CASTEiJ_G0028659
 protein coding gene Chr5:51102808-51135694 (+)
CBA/J MGP_CBAJ_G0029220
 protein coding gene Chr5:55870857-55906383 (+)
DBA/2J MGP_DBA2J_G0029366
 protein coding gene Chr5:50289889-50323269 (+)
FVB/NJ MGP_FVBNJ_G0029326
 protein coding gene Chr5:49628065-49661580 (+)
LP/J MGP_LPJ_G0029451
 protein coding gene Chr5:52526651-52560175 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029354
 protein coding gene Chr5:56957503-56993894 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030015
 protein coding gene Chr5:51424727-51459425 (+)
PWK/PhJ MGP_PWKPhJ_G0028383
 protein coding gene Chr5:49348909-49382565 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028217
 protein coding gene Chr5:50872417-50910378 (+)
WSB/EiJ MGP_WSBEiJ_G0028740
 protein coding gene Chr5:51487370-51524104 (+)



Homology
more
  • Human Ortholog
    SLC34A2, solute carrier family 34 member 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC34A2, solute carrier family 34 member 2
  • Synonyms
    NaPi2b, NAPI-3B, NAPI-IIb, NPTIIb, PULAM
  • Links
    NCBI Gene ID: 10568
    neXtProt AC: NX_O95436
    UniProt: O95436

  • Chr Location
    4p15.2; chr4:25648011-25678748 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human SLC34A2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 3 alleles in 3 genetic backgrounds
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display embryonic lethality, embryonic growth arrest, failure of embryo turning and somitogenesis, impaired placental development and impaired yolk sac vascular remodeling.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    793
  • Tissues
    62
  • cDNA Data
    59
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20531 NCBI Gene Model | MGI Sequence Detail 22312 C57BL/6J ±  kb
    transcript NM_011402 RefSeq | MGI Sequence Detail 4185 ZRU/MplStud  
    polypeptide Q9DBP0 UniProt | EBI | MGI Sequence Detail 697 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 65
      cDNA 59
      Primer pair 4
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1098602, MGI:2140766
    References
    more
    • Summaries
      All 79
      Developmental Gene Expression 8
      Gene Ontology 15
      Phenotypes 31
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:335704 Uehara Y, et al., Insights into pulmonary phosphate homeostasis and osteoclastogenesis emerge from the study of pulmonary alveolar microlithiasis. Nat Commun. 2023 Mar 2;14(1):1205
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory