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Lat Gene Detail
Summary
  • Symbol
    Lat
  • Name
    linker for activation of T cells
  • Feature Type
    protein coding gene
  • IDs
    MGI:1342293
    NCBI Gene: 16797
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:125962996-125968742 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 69.01 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    205 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1342293
 protein coding gene Chr7:125962996-125968877 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032975
 protein coding gene Chr7:130626321-130632005 (-)
A/J MGP_AJ_G0032958
 protein coding gene Chr7:127180150-127186273 (-)
AKR/J MGP_AKRJ_G0032890
 protein coding gene Chr7:130399469-130405142 (-)
BALB/cJ MGP_BALBcJ_G0032963
 protein coding gene Chr7:126838462-126844426 (-)
C3H/HeJ MGP_C3HHeJ_G0032673
 protein coding gene Chr7:130323549-130329199 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033469
 protein coding gene Chr7:135715506-135721295 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030441
 protein coding gene Chr7:128375358-128380987 (-)
CAST/EiJ MGP_CASTEiJ_G0032001
 protein coding gene Chr7:122109881-122115486 (-)
CBA/J MGP_CBAJ_G0032646
 protein coding gene Chr7:140288826-140296623 (-)
DBA/2J MGP_DBA2J_G0032798
 protein coding gene Chr7:125155763-125161416 (-)
FVB/NJ MGP_FVBNJ_G0032751
 protein coding gene Chr7:125002968-125008654 (-)
LP/J MGP_LPJ_G0032892
 protein coding gene Chr7:132091753-132097426 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032783
 protein coding gene Chr7:141482707-141489697 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033489
 protein coding gene Chr7:129416255-129421938 (-)
PWK/PhJ MGP_PWKPhJ_G0031709
 protein coding gene Chr7:118142800-118148822 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031555
 protein coding gene Chr7:116226189-116232001 (-)
WSB/EiJ MGP_WSBEiJ_G0032114
 protein coding gene Chr7:130376165-130383103 (-)



Homology
more
  • Human Ortholog
    LAT, linker for activation of T cells
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LAT, linker for activation of T cells
  • Synonyms
    IMD52, LAT1, pp36
  • Links
    NCBI Gene ID: 27040
    neXtProt AC: NX_O43561
    UniProt: O43561

  • Chr Location
    16p11.2; chr16:28984803-28990784 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Lat mouse models; 1 with human LAT associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    95 phenotypes from 12 alleles in 9 genetic backgrounds
    55 phenotypes from multigenic genotypes
    97 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit blockage of intra-thymic lymphocyte development at the double negative stage and absence of mature peripheral T cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    50
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    736
  • Tissues
    2
  • cDNA Data
    20
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030742 Ensembl Gene Model | MGI Sequence Detail 5747 C57BL/6J ±  kb
    transcript ENSMUST00000032997 Ensembl | MGI Sequence Detail 1235 Not Applicable  
    polypeptide ENSMUSP00000032997 Ensembl | MGI Sequence Detail 242 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000009683 linker for activation of T-cells family member 1
      (term hierarchy)
    • InterPro Domains
      IPR008359 Linker-for-activation of T cells (LAT) protein
    Molecular
    Reagents
    less
    • All nucleic 21
      cDNA 21

      Microarray probesets 3
    References
    more
    • Summaries
      All 149
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 15
      Phenotypes 97
    • Earliest
      J:49412 Zhang W, et al., LAT palmitoylation: its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation. Immunity. 1998 Aug;9(2):239-46
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory