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Klk8 Gene Detail
Summary
  • Symbol
    Klk8
  • Name
    kallikrein related-peptidase 8
  • Synonyms
    BSP1, Nrpn, Prss19
  • Feature Type
    protein coding gene
  • IDs
    MGI:1343327
    NCBI Gene: 259277
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:43447001-43453250 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 28.26 cM, cytoband B4
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    260 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1343327
 protein coding gene Chr7:43447001-43453250 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032143
 protein coding gene Chr7:43841353-43847598 (+)
A/J MGP_AJ_G0032128
 protein coding gene Chr7:42927538-42933778 (+)
AKR/J MGP_AKRJ_G0032058
 protein coding gene Chr7:44311620-44317865 (+)
BALB/cJ MGP_BALBcJ_G0032133
 protein coding gene Chr7:43044043-43050225 (+)
C3H/HeJ MGP_C3HHeJ_G0031849
 protein coding gene Chr7:44819628-44825741 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032617
 protein coding gene Chr7:46049372-46055639 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029640
 protein coding gene Chr7:45061756-45068136 (+)
CAST/EiJ MGP_CASTEiJ_G0031179
 protein coding gene Chr7:36008417-36017039 (+)
CBA/J MGP_CBAJ_G0031818
 protein coding gene Chr7:47513165-47519476 (+)
DBA/2J MGP_DBA2J_G0031967
 protein coding gene Chr7:42734349-42740628 (+)
FVB/NJ MGP_FVBNJ_G0031928
 protein coding gene Chr7:42445329-42451452 (+)
LP/J MGP_LPJ_G0032046
 protein coding gene Chr7:44566843-44573072 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031964
 protein coding gene Chr7:46436007-46442234 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032637
 protein coding gene Chr7:43438569-43444718 (+)
PWK/PhJ MGP_PWKPhJ_G0030900
 protein coding gene Chr7:36184840-36191143 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030739
 protein coding gene Chr7:31468765-31476726 (+)
WSB/EiJ MGP_WSBEiJ_G0031293
 protein coding gene Chr7:43987773-43994032 (+)



Homology
more
  • Human Ortholog
    KLK8, kallikrein related peptidase 8
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KLK8, kallikrein related peptidase 8
  • Synonyms
    HNP, NP, NRPN, PRSS19, TADG14
  • Links
    NCBI Gene ID: 11202
    neXtProt AC: NX_O60259
    UniProt: O60259

  • Chr Location
    19q13.41; chr19:50996007-51002711 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 3 alleles in 3 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a null allele show aberrant synapses and neurons in the hippocampus CA1 field. Homozygotes for another null allele have normal LTP and spatial reference memory but show increased polyspiking in response to repetitive afferent stimulation and enhanced kainite-induced seizure activity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    846
  • Tissues
    92
  • cDNA Data
    20
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 259277 NCBI Gene Model | MGI Sequence Detail 6250 C57BL/6J ±  kb
    transcript NM_008940 RefSeq | MGI Sequence Detail 1326 ZRU/MplStud  
    polypeptide Q61955 UniProt | EBI | MGI Sequence Detail 260 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 24
      Genomic 1
      cDNA 20
      Primer pair 1
      Other 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1202387
    References
    more
    • Summaries
      All 58
      Developmental Gene Expression 8
      Gene Ontology 16
      Phenotypes 19
    • Earliest
      J:26897 Chen ZL, et al., Expression and activity-dependent changes of a novel limbic-serine protease gene in the hippocampus. J Neurosci. 1995 Jul;15(7 Pt 2):5088-97
    • Latest
      J:347583 Barman B, et al., Neuropsin promotes hippocampal synaptogenesis by regulating the expression and cleavage of L1CAM. J Cell Sci. 2024 Feb 1;137(3):jcs261422
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory