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Commd8 Gene Detail
Summary
  • Symbol
    Commd8
  • Name
    COMM domain containing 8
  • Synonyms
    D5Buc26e, IMAGE:1958590
  • Feature Type
    protein coding gene
  • IDs
    MGI:1343485
    NCBI Gene: 27784
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:72313919-72325532 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 38.44 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    610 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1343485
 protein coding gene Chr5:72313918-72325532 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029610
 protein coding gene Chr5:72060176-72071805 (-)
A/J MGP_AJ_G0029578
 protein coding gene Chr5:69369474-69381081 (-)
AKR/J MGP_AKRJ_G0029526
 protein coding gene Chr5:71576189-71587795 (-)
BALB/cJ MGP_BALBcJ_G0029587
 protein coding gene Chr5:70036189-70047801 (-)
C3H/HeJ MGP_C3HHeJ_G0029310
 protein coding gene Chr5:71948527-71960132 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030041
 protein coding gene Chr5:75051551-75063167 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027281
 protein coding gene Chr5:65097360-65109726 (-)
CAST/EiJ MGP_CASTEiJ_G0028718
 protein coding gene Chr5:71072301-71083972 (-)
CBA/J MGP_CBAJ_G0029279
 protein coding gene Chr5:77442247-77453859 (-)
DBA/2J MGP_DBA2J_G0029425
 protein coding gene Chr5:69427750-69439354 (-)
FVB/NJ MGP_FVBNJ_G0029385
 protein coding gene Chr5:68608072-68619680 (-)
LP/J MGP_LPJ_G0029510
 protein coding gene Chr5:72545222-72556840 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029413
 protein coding gene Chr5:80841786-80854437 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030074
 protein coding gene Chr5:71174696-71186316 (-)
PWK/PhJ MGP_PWKPhJ_G0028442
 protein coding gene Chr5:68389191-68401096 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028276
 protein coding gene Chr5:70541320-70553352 (-)
WSB/EiJ MGP_WSBEiJ_G0028798
 protein coding gene Chr5:71418562-71430342 (-)



Homology
more
  • Human Ortholog
    COMMD8, COMM domain containing 8
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    COMMD8, COMM domain containing 8
  • Links
    NCBI Gene ID: 54951
    neXtProt AC: NX_Q9NX08
    UniProt: Q9NX08

  • Chr Location
    4p12; chr4:47450787-47463702 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional allele activated in B cells exhibit impaired B cell migration and humoral immune responses.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    85
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 27784 NCBI Gene Model | MGI Sequence Detail 11614 C57BL/6J ±  kb
    transcript NM_001356614 RefSeq | MGI Sequence Detail 4110 ZRU/MplStud  
    polypeptide Q9CZG3 UniProt | EBI | MGI Sequence Detail 183 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 94
      Genomic 8
      cDNA 85
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2141294
    References
    more
    • Summaries
      All 44
      Gene Ontology 3
      Phenotypes 18
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:337427 Shirai T, et al., Celastrol suppresses humoral immune responses and autoimmunity by targeting the COMMD3/8 complex. Sci Immunol. 2023 Mar 31;8(81):eadc9324
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory