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Zeb1 Gene Detail
Summary
  • Symbol
    Zeb1
  • Name
    zinc finger E-box binding homeobox 1
  • Synonyms
    3110032K11Rik, AREB6, [delta]EF1, MEB1, Nil2, Tcf18, Tcf8, Tw, ZEB, Zfhep, Zfhx1a, Zfx1a
  • Feature Type
    protein coding gene
  • IDs
    MGI:1344313
    NCBI Gene: 21417
  • Alliance
    gene page
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:5591860-5775467 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 4.42 cM
  • Mapping Data
    22 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3961 from dbSNP Build 142
  • Strain Annotations
    15
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1344313
 protein coding gene Chr18:5591330-5775468 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024127
 protein coding gene Chr18:2464905-2642516 (+)
A/J MGP_AJ_G0024089
 protein coding gene Chr18:2476286-2651367 (+)
AKR/J MGP_AKRJ_G0024057
 protein coding gene Chr18:2499985-2681602 (+)
BALB/cJ MGP_BALBcJ_G0024089
 protein coding gene Chr18:2450693-2634918 (+)
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0024534
 protein coding gene Chr18:2631428-2821669 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021973
 protein coding gene Chr18:2242748-2419338 (+)
CAST/EiJ MGP_CASTEiJ_G0023333
 protein coding gene Chr18:2451717-2650390 (+)
CBA/J MGP_CBAJ_G0023828
 protein coding gene Chr18:2599822-2798527 (+)
DBA/2J MGP_DBA2J_G0023956
 protein coding gene Chr18:2397069-2577232 (+)
FVB/NJ no annotation
LP/J MGP_LPJ_G0024040
 protein coding gene Chr18:2548622-2711312 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023950
 protein coding gene Chr18:2631843-2836058 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024579
 protein coding gene Chr18:2422002-2598218 (+)
PWK/PhJ MGP_PWKPhJ_G0023078
 protein coding gene Chr18:2386381-2573418 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022889
 protein coding gene Chr18:2713905-2905142 (+)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    ZEB1, zinc finger E-box binding homeobox 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZEB1, zinc finger E-box binding homeobox 1
  • Synonyms
    AREB6, BZP, DELTAEF1, FECD6, NIL2A, PPCD3, TCF8, ZFHEP, ZFHX1A
  • Links
    NCBI Gene ID: 6935
    neXtProt AC: NX_P37275
    UniProt: P37275

  • Chr Location
    10p11.22; chr10:31318417-31529814 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Zeb1 mouse models; 2 with human ZEB1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    189 phenotypes from 9 alleles in 16 genetic backgrounds
    14 phenotypes from multigenic genotypes
    5 images
    72 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutations at this locus affect thymus organization and homozygotes exhibit severe thymic T cell deficiency. Some mutations result in eye anomalies and extensive skeletal abnormalities. Homozygotes generally die at birth due to respiratory failure.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    64
  • GO References
    21
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1295
  • Tissues
    342
  • cDNA Data
    31
  • Literature Summary
    60
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024238 Ensembl Gene Model | MGI Sequence Detail 183608 C57BL/6J ±  kb
    transcript ENSMUST00000025081 Ensembl | MGI Sequence Detail 5801 Not Applicable  
    polypeptide ENSMUSP00000025081 Ensembl | MGI Sequence Detail 1117 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      10 Sequences
    • Protein Ontology
      PR:000017617 zinc finger E-box-binding homeobox 1
      (term hierarchy)
    • InterPro Domains
      IPR050636 C2H2-type zinc finger domain-containing protein
      IPR008598 Drought induced 19 protein type, zinc-binding domain
      IPR009057 Homeobox-like domain superfamily
      IPR036236 Zinc finger C2H2 superfamily
      IPR013087 Zinc finger C2H2-type
      IPR051574 Zinc finger E-box-binding homeobox
    • GlyGen
      Q64318 1 site, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 49
      Genomic 2
      cDNA 37
      Primer pair 5
      Other 5

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-14760, MGD-MRK-15303, MGD-MRK-19431, MGD-MRK-24149, MGI:1920415, MGI:98508, MGI:98871
    References
    more
    • Summaries
      All 190
      Developmental Gene Expression 60
      Diseases 1
      Gene Ontology 21
      Phenotypes 72
    • Earliest
      J:274 LYON MF, Twirler: a mutant affecting the inner ear of the house mouse. J Embryol Exp Morphol. 1958 Mar;6(1):105-16
    • Latest
      J:354217 Ohyama K, et al., Differentiation stage-specific expression of transcriptional regulators for epithelial mesenchymal transition in dentate granule progenitors. Front Neurosci. 2024;18:1425849
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory