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Rnf216 Gene Detail
Summary
  • Symbol
    Rnf216
  • Name
    ring finger protein 216
  • Synonyms
    2810055G22Rik, F830018F18Rik, Ubce7ip1, UIP83
  • Feature Type
    protein coding gene
  • IDs
    MGI:1344349
    NCBI Gene: 108086
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:142976648-143098749 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 81.86 cM, cytoband G2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2467 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1344349
 protein coding gene Chr5:142976648-143098793 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030321
 protein coding gene Chr5:148297051-148425237 (-)
A/J MGP_AJ_G0030290
 protein coding gene Chr5:141929596-142050283 (-)
AKR/J MGP_AKRJ_G0030222
 protein coding gene Chr5:146354928-146490458 (-)
BALB/cJ MGP_BALBcJ_G0030307
 protein coding gene Chr5:143173290-143294050 (-)
C3H/HeJ MGP_C3HHeJ_G0030018
 protein coding gene Chr5:147178922-147303862 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030752
 protein coding gene Chr5:153704836-153835585 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027970
 protein coding gene Chr5:135726518-135841117 (-)
CAST/EiJ MGP_CASTEiJ_G0029423
 protein coding gene Chr5:146664084-146786646 (-)
CBA/J MGP_CBAJ_G0029988
 protein coding gene Chr5:160014392-160154772 (-)
DBA/2J MGP_DBA2J_G0030138
 protein coding gene Chr5:141688606-141806497 (-)
FVB/NJ MGP_FVBNJ_G0030093
 protein coding gene Chr5:140897266-141015893 (-)
LP/J MGP_LPJ_G0030224
 protein coding gene Chr5:148892431-149016093 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030124
 protein coding gene Chr5:162481548-162599149 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030792
 protein coding gene Chr5:146214400-146337690 (-)
PWK/PhJ MGP_PWKPhJ_G0029138
 protein coding gene Chr5:140779258-140896668 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028974
 protein coding gene Chr5:143964826-144081618 (-)
WSB/EiJ MGP_WSBEiJ_G0029497
 protein coding gene Chr5:147014838-147137136 (-)



Homology
more
  • Human Ortholog
    RNF216, ring finger protein 216
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RNF216, ring finger protein 216
  • Synonyms
    CAHH, TRIAD3, U7I1, UBCE7IP1, ZIN
  • Links
    NCBI Gene ID: 54476
    neXtProt AC: NX_Q9NWF9
    UniProt: Q9NWF9

  • Chr Location
    7p22.1; chr7:5620047-5781696 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human RNF216 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 2 alleles in 3 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Nullizygous mutations of this gene result in male infertility associated with decreased testis size and weight, impaired spermatogenesis, decreased male germ cell number, and increased male germ cell apoptosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    36
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    16
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000045078 Ensembl Gene Model | MGI Sequence Detail 122102 C57BL/6J ±  kb
    transcript ENSMUST00000200607 Ensembl | MGI Sequence Detail 3704 Not Applicable  
    polypeptide ENSMUSP00000143705 Ensembl | MGI Sequence Detail 910 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 16

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:1914459, MGI:2140947, MGI:2141046, MGI:2141333, MGI:2442239
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 1
      Gene Ontology 7
      Phenotypes 19
    • Earliest
      J:56275 Martinez-Noel G, et al., A family of structurally related RING finger proteins interacts specifically with the ubiquitin-conjugating enzyme UbcM4. FEBS Lett. 1999 Jul 9;454(3):257-61
    • Latest
      J:352248 George AJ, et al., Gordon Holmes Syndrome Model Mice Exhibit Alterations in Microglia, Age, and Sex-Specific Disruptions in Cognitive and Proprioceptive Function. eNeuro. 2024 Jan;11(1):ENEURO.0074-23.2023
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory