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Dmtf1 Gene Detail
Summary
  • Symbol
    Dmtf1
  • Name
    cyclin D binding myb like transcription factor 1
  • Synonyms
    Dmp1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1344415
    NCBI Gene: 23857
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:9168868-9211782 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 3.69 cM, cytoband A2-A3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1105 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1344415
 protein coding gene Chr5:9168801-9211782 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029291
 protein coding gene Chr5:6122744-6172902 (-)
A/J MGP_AJ_G0029254
 protein coding gene Chr5:5962316-6005389 (-)
AKR/J MGP_AKRJ_G0029203
 protein coding gene Chr5:6060749-6103863 (-)
BALB/cJ MGP_BALBcJ_G0029271
 protein coding gene Chr5:6136287-6180605 (-)
C3H/HeJ MGP_C3HHeJ_G0028991
 protein coding gene Chr5:6296771-6341179 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029721
 protein coding gene Chr5:6681486-6724140 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026964
 protein coding gene Chr5:5679872-5720962 (-)
CAST/EiJ MGP_CASTEiJ_G0028404
 protein coding gene Chr5:6113041-6157390 (-)
CBA/J MGP_CBAJ_G0028952
 protein coding gene Chr5:6813561-6855403 (-)
DBA/2J MGP_DBA2J_G0029106
 protein coding gene Chr5:6076357-6119232 (-)
FVB/NJ MGP_FVBNJ_G0029068
 protein coding gene Chr5:5825581-5867521 (-)
LP/J MGP_LPJ_G0029195
 protein coding gene Chr5:6265746-6325388 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029096
 protein coding gene Chr5:6797511-6842590 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029752
 protein coding gene Chr5:6062864-6107518 (-)
PWK/PhJ MGP_PWKPhJ_G0028126
 protein coding gene Chr5:5846374-5889745 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027959
 protein coding gene Chr5:6238704-6283920 (-)
WSB/EiJ MGP_WSBEiJ_G0028484
 protein coding gene Chr5:6088923-6136644 (-)



Homology
more
  • Human Ortholog
    DMTF1, cyclin D binding myb like transcription factor 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DMTF1, cyclin D binding myb like transcription factor 1
  • Synonyms
    DMP1, DMTF, hDMP1, MRUL
  • Links
    NCBI Gene ID: 9988
    neXtProt AC: NX_Q9Y222
    UniProt: Q9Y222

  • Chr Location
    7q21.12; chr7:87152409-87196337 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 1 allele in 1 genetic background
    12 phenotypes from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants exhibit partial postnatal lethality, small size, and decreased thymocyte number. Some mutants exhibit seizures and/or obstructive uropathy. Males have dilated seminal vesicles. Mice develop spontaneous tumors in the second year of life, and are susceptible to induced tumors.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    800
  • Tissues
    92
  • cDNA Data
    22
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 23857 NCBI Gene Model | MGI Sequence Detail 42915 C57BL/6J ±  kb
    transcript NR_189319 RefSeq | MGI Sequence Detail 4283 C57BL/6  
    polypeptide Q8CE22 UniProt | EBI | MGI Sequence Detail 761 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 28
      Genomic 1
      cDNA 25
      Primer pair 2

      Microarray probesets 6
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 9
      Gene Ontology 4
      Phenotypes 14
    • Earliest
      J:51744 Hirai H, et al., Interaction of D-type cyclins with a novel myb-like transcription factor, DMP1. Mol Cell Biol. 1996 Nov;16(11):6457-67
    • Latest
      J:345749 Kendig RD, et al., Stabilization of the p53-DNA Complex by the Nuclear Protein Dmp1alpha. Cancer Invest. 2017 May 28;35(5):301-312
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    11/12/2024
    MGI 6.24     		The Jackson Laboratory