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Spry2 Gene Detail
Summary
  • Symbol
    Spry2
  • Name
    sprouty RTK signaling antagonist 2
  • Synonyms
    sprouty2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1345138
    NCBI Gene: 24064
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:106129381-106134253 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 56.16 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    166 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1345138
 protein coding gene Chr14:106129381-106134559 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021638
 protein coding gene Chr14:102484242-102492082 (-)
A/J MGP_AJ_G0021596
 protein coding gene Chr14:99103875-99108737 (-)
AKR/J MGP_AKRJ_G0021572
 protein coding gene Chr14:102078071-102082942 (-)
BALB/cJ MGP_BALBcJ_G0021602
 protein coding gene Chr14:99457648-99462510 (-)
C3H/HeJ MGP_C3HHeJ_G0021380
 protein coding gene Chr14:102008404-102016676 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022042
 protein coding gene Chr14:106604157-106609886 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019582
 protein coding gene Chr14:95851108-95855898 (-)
CAST/EiJ MGP_CASTEiJ_G0020897
 protein coding gene Chr14:99335434-99340194 (-)
CBA/J MGP_CBAJ_G0021348
 protein coding gene Chr14:110425726-110430556 (-)
DBA/2J MGP_DBA2J_G0021472
 protein coding gene Chr14:98616743-98621578 (-)
FVB/NJ MGP_FVBNJ_G0021449
 protein coding gene Chr14:97549098-97553941 (-)
LP/J MGP_LPJ_G0021540
 protein coding gene Chr14:103324503-103329346 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021476
 protein coding gene Chr14:113271989-113276872 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022065
 protein coding gene Chr14:101599850-101604725 (-)
PWK/PhJ MGP_PWKPhJ_G0020640
 protein coding gene Chr14:95556240-95561292 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020478
 protein coding gene Chr14:97592479-97599420 (-)
WSB/EiJ MGP_WSBEiJ_G0020950
 protein coding gene Chr14:102218636-102223497 (-)



Homology
more
  • Human Ortholog
    SPRY2, sprouty RTK signaling antagonist 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SPRY2, sprouty RTK signaling antagonist 2
  • Synonyms
    hSPRY2, IGAN3
  • Links
    NCBI Gene ID: 10253
    neXtProt AC: NX_O43597
    UniProt: O43597

  • Chr Location
    13q31.1; chr13:80335976-80341126 (-)  GRCh38
Human Diseases
more
  • Diseases
    3 with Spry2 mouse models; 1 with human SPRY2 associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 3 models
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    64 phenotypes from 4 alleles in 5 genetic backgrounds
    31 phenotypes from multigenic genotypes
    82 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit enteric nerve hyperplasia which led to esophangeal achalasia and intestinal pseudo-obstruction. Mice also have intermediate to severe hearing loss with abnormalities in the organ of Corti and about half die prematurely.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    82
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1071
  • Tissues
    260
  • cDNA Data
    14
  • Literature Summary
    203
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022114 Ensembl Gene Model | MGI Sequence Detail 4873 C57BL/6J ±  kb
    transcript ENSMUST00000022709 Ensembl | MGI Sequence Detail 2087 Not Applicable  
    polypeptide ENSMUSP00000022709 Ensembl | MGI Sequence Detail 315 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 40
      cDNA 16
      Primer pair 9
      Other 15

      Microarray probesets 4
    References
    more
    • Summaries
      All 311
      Developmental Gene Expression 203
      Diseases 4
      Gene Ontology 18
      Phenotypes 82
    • Earliest
      J:19710 Editors of Human Genome 1994, et al., Human genetic Disorders. J NIH Res. 1994;6:115-134
    • Latest
      J:353452 Altes G, et al., Multiple endocrine defects in adult-onset Sprouty1/2/4 triple knockout mice. Sci Rep. 2024 Aug 22;14(1):19479
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory