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Aadat Gene Detail
Summary
  • Symbol
    Aadat
  • Name
    aminoadipate aminotransferase
  • Synonyms
    Kat2, KATII, Kyat2, mKat-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1345167
    NCBI Gene: 23923
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:60958966-60998711 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 30.85 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1070 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1345167
 protein coding gene Chr8:60958877-60998711 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033629
 protein coding gene Chr8:60386496-60430151 (+)
A/J MGP_AJ_G0033611
 protein coding gene Chr8:57823861-57864853 (+)
AKR/J MGP_AKRJ_G0033536
 protein coding gene Chr8:59474478-59515687 (+)
BALB/cJ MGP_BALBcJ_G0033607
 protein coding gene Chr8:58076670-58113925 (+)
C3H/HeJ MGP_C3HHeJ_G0033317
 protein coding gene Chr8:60153640-60193463 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034124
 protein coding gene Chr8:62694548-62743370 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031072
 protein coding gene Chr8:53097783-53131157 (+)
CAST/EiJ MGP_CASTEiJ_G0032642
 protein coding gene Chr8:59561032-59605000 (+)
CBA/J MGP_CBAJ_G0033295
 protein coding gene Chr8:64985485-65024581 (+)
DBA/2J MGP_DBA2J_G0033449
 protein coding gene Chr8:57583733-57618917 (+)
FVB/NJ MGP_FVBNJ_G0033390
 protein coding gene Chr8:56907263-56942591 (+)
LP/J MGP_LPJ_G0033537
 protein coding gene Chr8:60357163-60400989 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033434
 protein coding gene Chr8:67111706-67150845 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034142
 protein coding gene Chr8:59728813-59776785 (+)
PWK/PhJ MGP_PWKPhJ_G0032351
 protein coding gene Chr8:56894928-56929866 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032187
 protein coding gene Chr8:58705961-58749996 (+)
WSB/EiJ MGP_WSBEiJ_G0032759
 protein coding gene Chr8:60075147-60113953 (+)



Homology
more
  • Human Ortholog
    AADAT, aminoadipate aminotransferase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AADAT, aminoadipate aminotransferase
  • Synonyms
    KAT2, KATII, KYAT2
  • Links
    NCBI Gene ID: 51166
    neXtProt AC: NX_Q8N5Z0
    UniProt: Q8N5Z0

  • Chr Location
    4q33
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice are viable and display earlier eye opening and development of air righting and open field crossing responses, and transient hyperactivity and neuronal abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    922
  • Tissues
    150
  • cDNA Data
    74
  • Literature Summary
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000057228 Ensembl Gene Model | MGI Sequence Detail 39746 C57BL/6J ±  kb
transcript ENSMUST00000209338 Ensembl | MGI Sequence Detail 1597 Not Applicable  
polypeptide ENSMUSP00000148060 Ensembl | MGI Sequence Detail 432 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 76
    cDNA 74
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGI:2142647
References
more
  • Summaries
    All 43
    Developmental Gene Expression 4
    Gene Ontology 8
    Phenotypes 11
  • Earliest
    J:56834 Yu P, et al., Genomic organization and expression analysis of mouse kynurenine aminotransferase II, a possible factor in the pathophysiology of Huntington's disease. Mamm Genome. 1999 Sep;10(9):845-52
  • Latest
    J:258106 Sathyasaikumar KV, et al., Xanthurenic Acid Formation from 3-Hydroxykynurenine in the Mammalian Brain: Neurochemical Characterization and Physiological Effects. Neuroscience. 2017 Dec 26;367:85-97
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory