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Slc11a2 Gene Detail
Summary
  • Symbol
    Slc11a2
  • Name
    solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
  • Synonyms
    DCT1, DMT1, microcytic anemia, viable anaemia, Nramp2, van
  • Feature Type
    protein coding gene
  • IDs
    MGI:1345279
    NCBI Gene: 18174
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:100285779-100322090 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 56.29 cM
  • Mapping Data
    11 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1173 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1345279
 protein coding gene Chr15:100285779-100322953 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022350
 protein coding gene Chr15:102345447-102382342 (-)
A/J MGP_AJ_G0022312
 protein coding gene Chr15:98311913-98349570 (-)
AKR/J MGP_AKRJ_G0022288
 protein coding gene Chr15:101315575-101352432 (-)
BALB/cJ MGP_BALBcJ_G0022316
 protein coding gene Chr15:98434141-98471398 (-)
C3H/HeJ MGP_C3HHeJ_G0022086
 protein coding gene Chr15:101395491-101432385 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022764
 protein coding gene Chr15:106184796-106222135 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020289
 protein coding gene Chr15:94085834-94122828 (-)
CAST/EiJ MGP_CASTEiJ_G0021611
 protein coding gene Chr15:102253208-102298907 (-)
CBA/J MGP_CBAJ_G0022055
 protein coding gene Chr15:109831799-109868968 (-)
DBA/2J MGP_DBA2J_G0022182
 protein coding gene Chr15:97679721-97716724 (-)
FVB/NJ MGP_FVBNJ_G0022161
 protein coding gene Chr15:96694066-96730937 (-)
LP/J MGP_LPJ_G0022253
 protein coding gene Chr15:102520389-102558607 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022182
 protein coding gene Chr15:113556499-113597732 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022778
 protein coding gene Chr15:101323787-101362775 (-)
PWK/PhJ MGP_PWKPhJ_G0021350
 protein coding gene Chr15:97805602-97843221 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021182
 protein coding gene Chr15:101218074-101290508 (-)
WSB/EiJ MGP_WSBEiJ_G0021661
 protein coding gene Chr15:101950806-101989170 (-)



Homology
more
  • Human Ortholog
    SLC11A2, solute carrier family 11 member 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC11A2, solute carrier family 11 member 2
  • Synonyms
    AHMIO1, DCT1, DMT1, NRAMP2
  • Links
    NCBI Gene ID: 4891
    neXtProt AC: NX_P49281
    UniProt: P49281

  • Chr Location
    12q13.12; chr12:50952263-51028886 (-)  GRCh38
Human Diseases
more
  • Diseases
    4 with human SLC11A2 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    45 phenotypes from 3 alleles in 7 genetic backgrounds
    6 phenotypes from multigenic genotypes
    67 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a spontaneous mutation exhibit microcytic, hypochromic anemia associated with impaired intestinal iron absorption and erythroblast iron uptake. Mutants have reduced viability and fertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    135
  • GO References
    27
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    735
  • Tissues
    17
  • cDNA Data
    14
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18174 NCBI Gene Model | MGI Sequence Detail 36312 C57BL/6J ±  kb
    transcript NM_001146161 RefSeq | MGI Sequence Detail 4373 ZRU/MplStud  
    polypeptide P49282 UniProt | EBI | MGI Sequence Detail 568 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 14
      Primer pair 5
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-12247, MGD-MRK-15380, MGD-MRK-24100, MGI:103229, MGI:96993
    References
    more
    • Summaries
      All 138
      Developmental Gene Expression 10
      Diseases 1
      Gene Ontology 27
      Phenotypes 67
    • Earliest
      J:5167 Russell ES, et al., Characterization and genetic studies of microcytic anemia in house mouse. Blood. 1970 Jun;35(6):838-50
    • Latest
      J:355025 Robertson KV, et al., Knockdown of microglial iron import gene, Slc11a2, worsens cognitive function and alters microglial transcriptional landscape in a sex-specific manner in the APP/PS1 model of Alzheimer's disease. J Neuroinflammation. 2024 Sep 27;21(1):238
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory