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Banf1 Gene Detail
Summary
  • Symbol
    Banf1
  • Name
    BAF nuclear assembly factor 1
  • Synonyms
    barrier to autointegration factor 1, Bcrp1, C78287
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346330
    NCBI Gene: 23825
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:5414661-5416904 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 4.31 cM, cytoband A
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    108 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346330
 protein coding gene Chr19:5414661-5417196 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024700
 protein coding gene Chr19:2322112-2324115 (-)
A/J MGP_AJ_G0024666
 protein coding gene Chr19:2197841-2199861 (-)
AKR/J MGP_AKRJ_G0024639
 protein coding gene Chr19:2259737-2261735 (-)
BALB/cJ MGP_BALBcJ_G0024666
 protein coding gene Chr19:2193957-2195956 (-)
C3H/HeJ MGP_C3HHeJ_G0024434
 protein coding gene Chr19:2265484-2267488 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025113
 protein coding gene Chr19:2381883-2383881 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022543
 protein coding gene Chr19:2104329-2106168 (-)
CAST/EiJ MGP_CASTEiJ_G0023906
 protein coding gene Chr19:2293345-2295348 (-)
CBA/J MGP_CBAJ_G0024406
 protein coding gene Chr19:2483509-2485517 (-)
DBA/2J MGP_DBA2J_G0024533
 protein coding gene Chr19:2176970-2178970 (-)
FVB/NJ MGP_FVBNJ_G0024500
 protein coding gene Chr19:2185207-2187233 (-)
LP/J MGP_LPJ_G0024619
 protein coding gene Chr19:2305237-2307242 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024530
 protein coding gene Chr19:2339541-2341336 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025161
 protein coding gene Chr19:2260819-2262817 (-)
PWK/PhJ MGP_PWKPhJ_G0023652
 protein coding gene Chr19:2215368-2217428 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023457
 protein coding gene Chr19:2250768-2252985 (-)
WSB/EiJ MGP_WSBEiJ_G0023968
 protein coding gene Chr19:2278139-2280144 (-)



Homology
more
  • Human Ortholog
    BANF1, barrier to autointegration nuclear assembly factor 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BANF1, barrier to autointegration nuclear assembly factor 1
  • Synonyms
    BAF, BCRP1, D14S1460, NGPS
  • Links
    NCBI Gene ID: 8815
    neXtProt AC: NX_O75531
    UniProt: O75531

  • Chr Location
    11q13.1; chr11:66002079-66004149 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human BANF1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    1 images
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show complete embryonic lethality prior to organogenesis. In vitro, blastocysts fail to hatch from the zona pellucida and die after 3 days in culture.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    43
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    105
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 23825 NCBI Gene Model | MGI Sequence Detail 2244 C57BL/6J ±  kb
    transcript NM_001286608 RefSeq | MGI Sequence Detail 1108 C57BL/6  
    polypeptide O54962 UniProt | EBI | MGI Sequence Detail 89 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 106
      cDNA 106

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2147785
    References
    more
    • Summaries
      All 47
      Gene Ontology 8
      Phenotypes 13
    • Earliest
      J:57554 Lee MS, et al., A previously unidentified host protein protects retroviral DNA from autointegration. Proc Natl Acad Sci U S A. 1998 Feb 17;95(4):1528-33
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory