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Cop1 Gene Detail
Summary
  • Symbol
    Cop1
  • Name
    COP1, E3 ubiquitin ligase
  • Synonyms
    Cop1, Rfwd2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347046
    NCBI Gene: 26374
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:159059890-159175210 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 69.03 cM, cytoband C3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2737 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1347046
 protein coding gene Chr1:159059734-159182442 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016637
 protein coding gene Chr1:164361353-164491823 (+)
A/J MGP_AJ_G0016618
 protein coding gene Chr1:157702017-157819284 (+)
AKR/J MGP_AKRJ_G0016584
 protein coding gene Chr1:162514777-162643292 (+)
BALB/cJ MGP_BALBcJ_G0016579
 protein coding gene Chr1:158258068-158377784 (+)
C3H/HeJ MGP_C3HHeJ_G0016403
 protein coding gene Chr1:162696975-162819980 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017040
 protein coding gene Chr1:169978729-170102905 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014749
 protein coding gene Chr1:149863157-149983850 (+)
CAST/EiJ MGP_CASTEiJ_G0015983
 protein coding gene Chr1:162294076-162422581 (+)
CBA/J MGP_CBAJ_G0016378
 protein coding gene Chr1:176002854-176135790 (+)
DBA/2J MGP_DBA2J_G0016484
 protein coding gene Chr1:156682195-156800548 (+)
FVB/NJ MGP_FVBNJ_G0016482
 protein coding gene Chr1:155100066-155217933 (+)
LP/J MGP_LPJ_G0016555
 protein coding gene Chr1:165480128-165601968 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016507
 protein coding gene Chr1:183507414-183655185 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017076
 protein coding gene Chr1:162362084-162475329 (+)
PWK/PhJ MGP_PWKPhJ_G0015769
 protein coding gene Chr1:155811864-155931235 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015556
 protein coding gene Chr1:161173475-161296597 (+)
WSB/EiJ MGP_WSBEiJ_G0016045
 protein coding gene Chr1:162512484-162635205 (+)



Homology
more
  • Human Ortholog
    COP1, COP1 E3 ubiquitin ligase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    COP1, COP1 E3 ubiquitin ligase
  • Synonyms
    CFAP78, FAP78, RFWD2, RNF200
  • Links
    NCBI Gene ID: 64326
    neXtProt AC: NX_Q8NHY2
    UniProt: Q8NHY2

  • Chr Location
    1q25.1-q25.2; chr1:175944831-176207286 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 5 alleles in 5 genetic backgrounds
    2 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional allele activated in prostate epithelial cells exhibit prostate gland hyperplasia and prostate intraepithelial neoplasia due to increased cell proliferation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    792
  • Tissues
    49
  • cDNA Data
    13
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000040782 Ensembl Gene Model | MGI Sequence Detail 115321 C57BL/6J ±  kb
    transcript ENSMUST00000076894 Ensembl | MGI Sequence Detail 5116 Not Applicable  
    polypeptide ENSMUSP00000076160 Ensembl | MGI Sequence Detail 733 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 13

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2138201, MGI:2138696, MGI:5927633
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 7
      Gene Ontology 9
      Phenotypes 15
    • Earliest
      J:56261 Wang H, et al., Evidence for functional conservation of a mammalian homologue of the light-responsive plant protein COP1. Curr Biol. 1999 Jul 1;9(13):711-4
    • Latest
      J:338217 Su Y, et al., Glucose-induced CRL4(COP1)-p53 axis amplifies glycometabolism to drive tumorigenesis. Mol Cell. 2023 Jul 6;83(13):2316-2331.e7
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory