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Fgd2 Gene Detail
Summary
  • Symbol
    Fgd2
  • Name
    FYVE, RhoGEF and PH domain containing 2
  • Synonyms
    Tcd-2, Tcd2, tcs-2, tcs2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347084
    NCBI Gene: 26382
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:29579878-29598509 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 15.26 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    744 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1347084
 protein coding gene Chr17:29579878-29598635 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023464
 protein coding gene Chr17:28889044-28909713 (+)
A/J MGP_AJ_G0023422
 protein coding gene Chr17:27911738-27931464 (+)
AKR/J MGP_AKRJ_G0023387
 protein coding gene Chr17:28136664-28161123 (+)
BALB/cJ MGP_BALBcJ_G0023427
 protein coding gene Chr17:28160722-28179571 (+)
C3H/HeJ MGP_C3HHeJ_G0023188
 protein coding gene Chr17:28517956-28536732 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023869
 protein coding gene Chr17:30034879-30055967 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021344
 protein coding gene Chr17:25220700-25240234 (+)
CAST/EiJ MGP_CASTEiJ_G0022689
 protein coding gene Chr17:28489996-28509203 (+)
CBA/J MGP_CBAJ_G0023163
 protein coding gene Chr17:31165256-31185917 (+)
DBA/2J MGP_DBA2J_G0023293
 protein coding gene Chr17:27425316-27444048 (+)
FVB/NJ MGP_FVBNJ_G0023263
 protein coding gene Chr17:27259991-27279941 (+)
LP/J MGP_LPJ_G0023371
 protein coding gene Chr17:29142323-29163539 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023281
 protein coding gene Chr17:30493002-30515075 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023911
 protein coding gene Chr17:28599323-28618819 (+)
PWK/PhJ MGP_PWKPhJ_G0022439
 protein coding gene Chr17:26261974-26282669 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022257
 protein coding gene Chr17:26584320-26608665 (+)
WSB/EiJ MGP_WSBEiJ_G0022751
 protein coding gene Chr17:28557740-28577727 (+)



Homology
more
  • Human Ortholog
    FGD2, FYVE, RhoGEF and PH domain containing 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FGD2, FYVE, RhoGEF and PH domain containing 2
  • Synonyms
    ZFYVE4
  • Links
    NCBI Gene ID: 221472
    neXtProt AC: NX_Q7Z6J4
    UniProt: Q7Z6J4

  • Chr Location
    6p21.2; chr6:37005646-37029069 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from multigenic genotypes
    6 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    23
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 26382 NCBI Gene Model | MGI Sequence Detail 18632 C57BL/6J ±  kb
transcript NM_001159538 RefSeq | MGI Sequence Detail 2634 ZRU/MplStud  
polypeptide Q8BY35 UniProt | EBI | MGI Sequence Detail 655 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 24
    cDNA 23
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-14738, MGD-MRK-14743, MGD-MRK-14932, MGD-MRK-14935, MGI:98500
References
more
  • Summaries
    All 37
    Gene Ontology 4
    Phenotypes 6
  • Earliest
    J:7443 Lyon MF, Transmission ratio distortion in mouse t-haplotypes is due to multiple distorter genes acting on a responder locus. Cell. 1984 Jun;37(2):621-8
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory