About   Help   FAQ
Pnck Gene Detail
Summary
  • Symbol
    Pnck
  • Name
    pregnancy upregulated non-ubiquitously expressed CaM kinase
  • Synonyms
    Bstk3, Camk1b, CaMKIbeta2, Punc
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347357
    NCBI Gene: 93843
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:72699600-72703723 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 37.38 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    118 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1347357
 protein coding gene ChrX:72699598-72703723 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035814
 protein coding gene ChrX:69424226-69428357 (-)
A/J MGP_AJ_G0035795
 protein coding gene ChrX:69623462-69627568 (-)
AKR/J MGP_AKRJ_G0035720
 protein coding gene ChrX:71432718-71436841 (-)
BALB/cJ MGP_BALBcJ_G0035780
 protein coding gene ChrX:68657305-68661428 (-)
C3H/HeJ MGP_C3HHeJ_G0035485
 protein coding gene ChrX:69896748-69901999 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036310
 protein coding gene ChrX:71556707-71560830 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033154
 protein coding gene ChrX:68661384-68665479 (-)
CAST/EiJ MGP_CASTEiJ_G0034776
 protein coding gene ChrX:55244628-55248775 (-)
CBA/J MGP_CBAJ_G0035460
 protein coding gene ChrX:73508986-73513109 (-)
DBA/2J MGP_DBA2J_G0035617
 protein coding gene ChrX:69086726-69090849 (-)
FVB/NJ MGP_FVBNJ_G0035561
 protein coding gene ChrX:68414654-68419188 (-)
LP/J MGP_LPJ_G0035702
 protein coding gene ChrX:70209792-70213923 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035599
 protein coding gene ChrX:76093727-76097850 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036332
 protein coding gene ChrX:69248235-69252366 (-)
PWK/PhJ MGP_PWKPhJ_G0034475
 protein coding gene ChrX:53259556-53263678 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034309
 protein coding gene ChrX:56153837-56157955 (-)
WSB/EiJ MGP_WSBEiJ_G0034917
 protein coding gene ChrX:68517301-68521424 (-)



Homology
more
  • Human Ortholog
    PNCK, pregnancy up-regulated nonubiquitous CaM kinase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PNCK, pregnancy up-regulated nonubiquitous CaM kinase
  • Synonyms
    BSTK3, CaMK1b
  • Links
    NCBI Gene ID: 139728
    neXtProt AC: NX_Q6P2M8
    UniProt: Q6P2M8

  • Chr Location
    Xq28; chrX:153669733-153689010 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 2 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    970
  • Tissues
    158
  • cDNA Data
    26
  • Literature Summary
    7
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000002012 Ensembl Gene Model | MGI Sequence Detail 4124 C57BL/6J ±  kb
transcript ENSMUST00000114473 Ensembl | MGI Sequence Detail 1492 Not Applicable  
polypeptide ENSMUSP00000110117 Ensembl | MGI Sequence Detail 343 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000012923 calcium/calmodulin-dependent protein kinase type 1B
    (term hierarchy)
  • EC
    2.7.11.17
  • InterPro Domains
    IPR042696 Calcium/calmodulin-dependent protein kinase type 1B, catalytic domain
    IPR017441 Protein kinase, ATP binding site
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain superfamily
    IPR008271 Serine/threonine-protein kinase, active site
  • GlyGen
    Q9QYK9 1 site, 1 N-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 32
    cDNA 26
    Primer pair 3
    Other 3

    Microarray probesets 5
Other
Accession IDs
less
MGI:1349655
References
more
  • Summaries
    All 40
    Developmental Gene Expression 7
    Gene Ontology 6
    Phenotypes 7
  • Earliest
    J:44157 Chodosh LA, et al., Mammary gland development, reproductive history, and breast cancer risk. Cancer Res. 1999 Apr 1;59(7 Suppl):1765-1771s; discussion 1771s-1
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory