Cul3 MGI Mouse Gene Detail - MGI:1347360

Symbol

Cul3
Name

cullin 3

Feature Type

protein coding gene
IDs

MGI:1347360
NCBI Gene: 26554
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr1:80242640-80318197 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 41.24 cM, cytoband C4
Mapping Data

4 experiments

SNPs within 2kb

1546 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1347360	protein coding gene	Chr1:80242640-80318426 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0016210	protein coding gene	Chr1:81076097-81155573 (-)
A/J	MGP_AJ_G0016193	protein coding gene	Chr1:78213844-78290054 (-)
AKR/J	MGP_AKRJ_G0016150	protein coding gene	Chr1:80354792-80432550 (-)
BALB/cJ	MGP_BALBcJ_G0016148	protein coding gene	Chr1:78296662-78373895 (-)
C3H/HeJ	MGP_C3HHeJ_G0015978	protein coding gene	Chr1:80701140-80777230 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0016601	protein coding gene	Chr1:84225283-84302136 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014321	protein coding gene	Chr1:73532296-73605406 (-)
CAST/EiJ	MGP_CASTEiJ_G0015563	protein coding gene	Chr1:80069089-80149751 (-)
CBA/J	MGP_CBAJ_G0015952	protein coding gene	Chr1:86904247-86983547 (-)
DBA/2J	MGP_DBA2J_G0016053	protein coding gene	Chr1:77521897-77598001 (-)
FVB/NJ	MGP_FVBNJ_G0016056	protein coding gene	Chr1:76661254-76737219 (-)
LP/J	MGP_LPJ_G0016126	protein coding gene	Chr1:82221059-82299668 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016076	protein coding gene	Chr1:90168448-90271264 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016648	protein coding gene	Chr1:80469656-80552406 (-)
PWK/PhJ	MGP_PWKPhJ_G0015349	protein coding gene	Chr1:76931748-77008296 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0015127	protein coding gene	Chr1:79742543-79822538 (-)
WSB/EiJ	MGP_WSBEiJ_G0015624	protein coding gene	Chr1:80245879-80324778 (-)

Human Ortholog

CUL3, cullin 3

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CUL3, cullin 3
Synonyms

CUL-3, NEDAUS, PHA2E
Links

HGNC:2553

NCBI Gene ID: 8452

neXtProt AC: NX_Q13618

UniProt: Q13618
Chr Location

2q36.2; chr2:224470150-224585397 (-) GRCh38

MGI Vertebrate Homology

Cul3 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: CUL3
Gene Tree

Cul3

Diseases

1 with human CUL3 associations

Human Disease

Mouse Models

pseudohypoaldosteronism

IDs

View 2 "NOT" models

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

2 with disease annotations

References

1 with disease annotations

less

Phenotype Summary

72 phenotypes from 7 alleles in 8 genetic backgrounds
38 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

38
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

24
Radiation induced

1
Targeted

9
Genomic Mutations

2 involving Cul3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

51 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for a targeted null mutation accumulate cyclin E, exhibit abnormal cycling in cells of extraembryonic ectoderm and trophectoderm, reduced size, abnormal gastrulation and trophoblast cells, absence of an amnion, and death by embryonic day 7.5. Conditional heterozygous KO in neuronal cells causes social deficits and anxiety-like behavior, while homozygous neuronal KO leads to brain abnormalities, small body size and death before weaning.

less

All GO Annotations

115
GO References

19

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

733
Tissues

20
cDNA Data

200
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cul3

ZFIN cul3a

less

All Sequences

65
RefSeq

12
UniProt

6
CCDS

CCDS15094.1

Ensembl

ENSMUSG00000004364 (Evidence)
NCBI Gene

26554

			Length	Strain/Species	Flank
genomic	ENSMUSG00000004364	Ensembl Gene Model \| MGI Sequence Detail	75558	C57BL/6J	± kb
transcript	ENSMUST00000163119	Ensembl \| MGI Sequence Detail	4709	Not Applicable
polypeptide	ENSMUSP00000130738	Ensembl \| MGI Sequence Detail	768	Not Applicable

less

UniProt

6 Sequences
Protein Ontology

PR:000006048 cullin-3

(term hierarchy)
PDB

1IUY
InterPro Domains

IPR045093 Cullin

IPR016157 Cullin, conserved site

IPR016158 Cullin homology domain

IPR036317 Cullin homology domain superfamily

IPR001373 Cullin, N-terminal

IPR019559 Cullin protein, neddylation domain

IPR016159 Cullin repeat-like-containing domain superfamily

IPR036390 Winged helix DNA-binding domain superfamily

IPR036388 Winged helix-like DNA-binding domain superfamily
GlyGen

Q9JLV5 4 sites, 2 N-linked glycans (3 sites), 1 O-linked glycan (1 site)

less

All nucleic 200

cDNA 200

Microarray probesets 7

less

MGI:2138270, MGI:2138569

Summaries

All 90

Developmental Gene Expression 9

Diseases 1

Gene Ontology 19

Phenotypes 38
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:354821 Gao N, et al., Deficiency of Cullin 3, a Protein Encoded by a Schizophrenia and Autism Risk Gene, Impairs Behaviors by Enhancing the Excitability of Ventral Tegmental Area (VTA) DA Neurons. J Neurosci. 2023 Sep 6;43(36):6249-6267

TSS for Cul3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr12469	Chr1:80318397-80318537 (-)	-270 bp
Tssr12468	Chr1:80318370-80318392 (-)	-184 bp
Tssr12467	Chr1:80318334-80318365 (-)	-153 bp
Tssr12466	Chr1:80318319-80318330 (-)	-128 bp
Tssr12465	Chr1:80318249-80318260 (-)	-58 bp
Tssr12464	Chr1:80318218-80318229 (-)	-27 bp
Tssr12463	Chr1:80318101-80318112 (-)	90 bp
Tssr12462	Chr1:80318060-80318071 (-)	131 bp
Tssr12460	Chr1:80267597-80267601 (-)	50,598 bp
Tssr12459	Chr1:80267455-80267474 (-)	50,732 bp
Tssr12458	Chr1:80265378-80265382 (-)	52,817 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24