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Spag1 Gene Detail
Summary
  • Symbol
    Spag1
  • Name
    sperm associated antigen 1
  • Synonyms
    tpis, TPR-containing protein involved in spermatogenesis
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349387
    NCBI Gene: 26942
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:36178245-36235767 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 14.46 cM, cytoband C
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1935 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1349387
 protein coding gene Chr15:36175629-36235767 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021792
 protein coding gene Chr15:34557595-34614238 (+)
A/J MGP_AJ_G0021753
 protein coding gene Chr15:33260032-33314945 (+)
AKR/J MGP_AKRJ_G0021731
 protein coding gene Chr15:34182057-34239805 (+)
BALB/cJ MGP_BALBcJ_G0021759
 protein coding gene Chr15:33268061-33325650 (+)
C3H/HeJ MGP_C3HHeJ_G0021534
 protein coding gene Chr15:34150561-34209527 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022198
 protein coding gene Chr15:35864708-35920329 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019736
 protein coding gene Chr15:31070659-31131650 (+)
CAST/EiJ MGP_CASTEiJ_G0021050
 protein coding gene Chr15:34553324-34615669 (+)
CBA/J MGP_CBAJ_G0021503
 protein coding gene Chr15:37027646-37089982 (+)
DBA/2J MGP_DBA2J_G0021627
 protein coding gene Chr15:33082811-33139807 (+)
FVB/NJ MGP_FVBNJ_G0021605
 protein coding gene Chr15:32482587-32538424 (+)
LP/J MGP_LPJ_G0021696
 protein coding gene Chr15:34461106-34521133 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021629
 protein coding gene Chr15:40143662-40210806 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022221
 protein coding gene Chr15:34335571-34392313 (+)
PWK/PhJ MGP_PWKPhJ_G0020794
 protein coding gene Chr15:33101041-33159535 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020632
 protein coding gene Chr15:34031664-34091889 (+)
WSB/EiJ MGP_WSBEiJ_G0021106
 protein coding gene Chr15:34301806-34359827 (+)



Homology
more
  • Human Ortholog
    SPAG1, sperm associated antigen 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SPAG1, sperm associated antigen 1
  • Synonyms
    CILD28, CT140, DNAAF13, HEL-S-268, HSD-3.8, SP75, TPIS
  • Links
    NCBI Gene ID: 6674
    neXtProt AC: NX_Q07617
    UniProt: Q07617

  • Chr Location
    8q22.2; chr8:100157906-100259278 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human SPAG1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    759
  • Tissues
    39
  • cDNA Data
    28
  • Literature Summary
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000037617 Ensembl Gene Model | MGI Sequence Detail 57523 C57BL/6J ±  kb
transcript ENSMUST00000047348 Ensembl | MGI Sequence Detail 3646 Not Applicable  
polypeptide ENSMUSP00000047335 Ensembl | MGI Sequence Detail 901 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000015452 sperm-associated antigen 1
    (term hierarchy)
  • InterPro Domains
    IPR051982 Ciliary Assembly and Mitochondrial Import
    IPR025986 RNA-polymerase II-associated protein 3-like, C-terminal domain
    IPR011990 Tetratricopeptide-like helical domain superfamily
    IPR019734 Tetratricopeptide repeat
Molecular
Reagents
less
  • All nucleic 29
    cDNA 28
    Other 1

    Microarray probesets 4
References
more
  • Summaries
    All 36
    Developmental Gene Expression 2
    Gene Ontology 6
    Phenotypes 10
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory