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Gcat Gene Detail
Summary
  • Symbol
    Gcat
  • Name
    glycine C-acetyltransferase (2-amino-3-ketobutyrate-coenzyme A ligase)
  • Synonyms
    aminoacetone synthase, Kbl
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349389
    NCBI Gene: 26912
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:78915074-78926731 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 37.70 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    364 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1349389
 protein coding gene Chr15:78915074-78926731 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022061
 protein coding gene Chr15:79285801-79298154 (+)
A/J MGP_AJ_G0022022
 protein coding gene Chr15:76544234-76558491 (+)
AKR/J MGP_AKRJ_G0021997
 protein coding gene Chr15:78663553-78677906 (+)
BALB/cJ MGP_BALBcJ_G0022028
 protein coding gene Chr15:76518251-76531338 (+)
C3H/HeJ MGP_C3HHeJ_G0021799
 protein coding gene Chr15:78668146-78681733 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022471
 protein coding gene Chr15:82394362-82407402 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020001
 protein coding gene Chr15:73027757-73040188 (+)
CAST/EiJ MGP_CASTEiJ_G0021320
 protein coding gene Chr15:79359757-79373642 (+)
CBA/J MGP_CBAJ_G0021764
 protein coding gene Chr15:84947508-84963060 (+)
DBA/2J MGP_DBA2J_G0021893
 protein coding gene Chr15:76024448-76037233 (+)
FVB/NJ MGP_FVBNJ_G0021871
 protein coding gene Chr15:75043980-75056290 (+)
LP/J MGP_LPJ_G0021961
 protein coding gene Chr15:79469860-79485691 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021891
 protein coding gene Chr15:90101242-90115106 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022485
 protein coding gene Chr15:78689103-78701454 (+)
PWK/PhJ MGP_PWKPhJ_G0021062
 protein coding gene Chr15:76029258-76042914 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020899
 protein coding gene Chr15:78484101-78500206 (+)
WSB/EiJ MGP_WSBEiJ_G0021372
 protein coding gene Chr15:79064839-79080106 (+)



Homology
more
  • Human Ortholog
    GCAT, glycine C-acetyltransferase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GCAT, glycine C-acetyltransferase
  • Synonyms
    KBL
  • Links
    NCBI Gene ID: 23464
    neXtProt AC: NX_O75600
    UniProt: O75600

  • Chr Location
    22q13.1; chr22:37807905-37817183 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    26 phenotype references
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Gene trapped
    4
  • Radiation induced
    2
  • Targeted
    1
  • Genomic Mutations
    3 involving Gcat
  • Incidental Mutations
    APF , CvDC
  • Find Mice (IMSR)
    21 strains or lines available
Mice homozygous for a knock-out allele exhibit no gross abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    326
  • Tissues
    123
  • cDNA Data
    88
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 26912 NCBI Gene Model | MGI Sequence Detail 11658 C57BL/6J ±  kb
transcript NM_013847 RefSeq | MGI Sequence Detail 2373 ZRU/MplStud  
polypeptide O88986 UniProt | EBI | MGI Sequence Detail 416 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000007885 2-amino-3-ketobutyrate coenzyme A ligase
    (term hierarchy)
  • EC
    2.3.1.29
  • InterPro Domains
    IPR011282 2-amino-3-ketobutyrate coenzyme A ligase
    IPR050087 8-amino-7-oxononanoate synthase class-II
    IPR004839 Aminotransferase, class I/classII
    IPR001917 Aminotransferase, class-II, pyridoxal-phosphate binding site
    IPR015424 Pyridoxal phosphate-dependent transferase
    IPR015421 Pyridoxal phosphate-dependent transferase, major domain
    IPR015422 Pyridoxal phosphate-dependent transferase, small domain
  • GlyGen
    O88986 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 92
    cDNA 90
    Primer pair 2

    Microarray probesets 5
Other
Accession IDs
less
MGI:2146035
References
more
  • Summaries
    All 60
    Developmental Gene Expression 4
    Diseases 1
    Gene Ontology 10
    Phenotypes 26
  • Earliest
    J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
  • Latest
    J:285676 Suzuki A, et al., Genes and microRNAs associated with mouse cleft palate: A systematic review and bioinformatics analysis. Mech Dev. 2018 Apr;150:21-27
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory