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Clec4a2 Gene Detail
Summary
  • Symbol
    Clec4a2
  • Name
    C-type lectin domain family 4, member a2
  • Synonyms
    Clecsf6, DCIR, Dcir1, dendritic cell immunoreceptor
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349412
    NCBI Gene: 26888
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:123099627-123119891 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 58.18 cM, cytoband F3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    690 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1349412
 protein coding gene Chr6:123083387-123120958 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031240
 protein coding gene Chr6:126248285-126293614 (+)
A/J MGP_AJ_G0031209
 protein coding gene Chr6:121433922-121466762 (+)
AKR/J MGP_AKRJ_G0031139
 protein coding gene Chr6:124800311-124840014 (+)
BALB/cJ MGP_BALBcJ_G0031219
 protein coding gene Chr6:121160473-121190229 (+)
C3H/HeJ MGP_C3HHeJ_G0030938
 protein coding gene Chr6:124757535-124791528 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031678
 protein coding gene Chr6:129573887-129609412 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028833
 protein coding gene Chr6:118027577-118045381 (+)
CAST/EiJ MGP_CASTEiJ_G0030327
 protein coding gene Chr6:125026259-125063512 (+)
CBA/J MGP_CBAJ_G0030901
 protein coding gene Chr6:134631708-134688586 (+)
DBA/2J MGP_DBA2J_G0031057
 protein coding gene Chr6:120380123-120417440 (+)
FVB/NJ no annotation
LP/J MGP_LPJ_G0031138
 protein coding gene Chr6:126428535-126459776 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031045
 protein coding gene Chr6:138577229-138618609 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031707
 protein coding gene Chr6:124693204-124729314 (+)
PWK/PhJ MGP_PWKPhJ_G0030041
 protein coding gene Chr6:119211693-119237364 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029868
 protein coding gene Chr6:122817408-122855180 (+)
WSB/EiJ MGP_WSBEiJ_G0030409
 protein coding gene Chr6:124994888-125032477 (+)



Homology
more
  • Human Ortholog
    CLEC4A, C-type lectin domain family 4 member A
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CLEC4A, C-type lectin domain family 4 member A
  • Synonyms
    CD367, CLECSF6, DCIR, DDB27, HDCGC13P, hDCIR, LLIR
  • Links
    NCBI Gene ID: 50856
    neXtProt AC: NX_Q9UMR7
    UniProt: Q9UMR7

  • Chr Location
    12p13.31; chr12:8102907-8138607 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    28 phenotypes from 2 alleles in 2 genetic backgrounds
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased IgG2a, IgG2b and IgG3 levels, increased B cell proliferation, enlarged lymph nodes and degeneration of seminiferous tubules.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    19
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 26888 NCBI Gene Model | MGI Sequence Detail 20265 C57BL/6J ±  kb
    transcript NM_001170333 RefSeq | MGI Sequence Detail 1473 ZRU/MplStud  
    polypeptide Q9QZ15 UniProt | EBI | MGI Sequence Detail 238 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 19

      Microarray probesets 5
    References
    more
    • Summaries
      All 51
      Gene Ontology 6
      Phenotypes 24
    • Earliest
      J:56741 Bates EE, et al., APCs express DCIR, a novel C-type lectin surface receptor containing an immunoreceptor tyrosine-based inhibitory motif. J Immunol. 1999 Aug 15;163(4):1973-83
    • Latest
      J:346737 Trimaglio G, et al., The C-type lectin DCIR contributes to the immune response and pathogenesis of colorectal cancer. Sci Rep. 2024 Mar 26;14(1):7199
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory