About   Help   FAQ
Eif2s3y Gene Detail
Summary
  • Symbol
    Eif2s3y
  • Name
    eukaryotic translation initiation factor 2, subunit 3, structural gene Y-linked
  • Synonyms
    Eif-2gy, Spy, Tfy
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349430
    NCBI Gene: 26908
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    ChrY:1010543-1028847 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome Y, Syntenic
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    21 from dbSNP Build 142
  • Strain Annotations
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1349430
 protein coding gene ChrY:1010543-1049136 (+)
129S1/SvImJ no annotation
A/J no annotation
AKR/J no annotation
BALB/cJ no annotation
C3H/HeJ no annotation
C57BL/6NJ no annotation
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J no annotation
FVB/NJ no annotation
LP/J no annotation
NOD/ShiLtJ no annotation
NZO/HlLtJ no annotation
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
less
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 3 alleles in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Hemizygous knockout leads to male infertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    738
  • Tissues
    14
  • cDNA Data
    36
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000069049 Ensembl Gene Model | MGI Sequence Detail 18305 C57BL/6J ±  kb
    transcript ENSMUST00000091197 Ensembl | MGI Sequence Detail 1836 Not Applicable  
    polypeptide ENSMUSP00000088736 Ensembl | MGI Sequence Detail 472 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000007287 eukaryotic translation initiation factor 2 subunit 3, Y-linked
      (term hierarchy)
    • EC
      3.6.5.3
    • InterPro Domains
      IPR050543 Eukaryotic Initiation Factor 2 Gamma Subunit
      IPR015256 Initiation factor eIF2 gamma, C-terminal
      IPR044127 Initiation factor eIF2 gamma, domain 2
      IPR044128 Initiation factor eIF2 gamma, GTP-binding domain
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
      IPR000795 Translational (tr)-type GTP-binding domain
      IPR009001 Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal
      IPR004161 Translation elongation factor EFTu-like, domain 2
      IPR009000 Translation protein, beta-barrel domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 46
      Genomic 6
      cDNA 37
      Primer pair 1
      Other 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-14552, MGI:98394
    References
    more
    • Summaries
      All 58
      Developmental Gene Expression 8
      Gene Ontology 5
      Phenotypes 15
    • Earliest
      J:7773 Mather PB, et al., Biochemical genetics of aldehyde dehydrogenase isozymes in the mouse: evidence for stomach- and testis-specific isozymes. Biochem Genet. 1984 Dec;22(11-12):981-95
    • Latest
      J:331366 Song Y, et al., Loss of circSRY reduces gammaH2AX level in germ cells and impairs mouse spermatogenesis. Life Sci Alliance. 2023 Feb;6(2)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory