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Eif2s3x Gene Detail
Summary
  • Symbol
    Eif2s3x
  • Name
    eukaryotic translation initiation factor 2, subunit 3, structural gene X-linked
  • Synonyms
    Eif-2gx
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349431
    NCBI Gene: 26905
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:93232315-93256257 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 41.52 cM, cytoband C-D
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    634 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1349431
 protein coding gene ChrX:93232313-93256468 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035908
 protein coding gene ChrX:90584524-90608732 (-)
A/J MGP_AJ_G0035894
 protein coding gene ChrX:90685119-90711430 (-)
AKR/J MGP_AKRJ_G0035811
 protein coding gene ChrX:93072772-93107157 (-)
BALB/cJ MGP_BALBcJ_G0035878
 protein coding gene ChrX:89386883-89410945 (-)
C3H/HeJ MGP_C3HHeJ_G0035587
 protein coding gene ChrX:90945146-90978416 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036407
 protein coding gene ChrX:93348154-93375440 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033234
 protein coding gene ChrX:88832928-88856925 (-)
CAST/EiJ MGP_CASTEiJ_G0034872
 protein coding gene ChrX:75618534-75654265 (-)
CBA/J MGP_CBAJ_G0035561
 protein coding gene ChrX:96040696-96067931 (-)
DBA/2J MGP_DBA2J_G0035717
 protein coding gene ChrX:89914972-89939549 (-)
FVB/NJ MGP_FVBNJ_G0035656
 protein coding gene ChrX:89302545-89334083 (-)
LP/J MGP_LPJ_G0035806
 protein coding gene ChrX:91377126-91402370 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035690
 protein coding gene ChrX:100328251-100366229 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036434
 protein coding gene ChrX:90300854-90326403 (-)
PWK/PhJ MGP_PWKPhJ_G0034571
 protein coding gene ChrX:73397064-73421812 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034401
 protein coding gene ChrX:76470740-76496204 (-)
WSB/EiJ MGP_WSBEiJ_G0035013
 protein coding gene ChrX:89096983-89122575 (-)



Homology
more
  • Human Ortholog
    EIF2S3, eukaryotic translation initiation factor 2 subunit gamma
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EIF2S3, eukaryotic translation initiation factor 2 subunit gamma
  • Synonyms
    EIF2, EIF2G, eIF-2gA, EIF2gamma, eIF2gX, MEHMO, MRXSBRK
  • Links
    NCBI Gene ID: 1968
    neXtProt AC: NX_P41091
    UniProt: P41091

  • Chr Location
    Xp22.11; chrX:24054946-24078810 (+)  GRCh38
  • Human Ortholog
    EIF2S3B, eukaryotic translation initiation factor 2 subunit gamma B
  • Synonyms
    eIF-2gA, eIF2gA, EIF2S3L
  • Links
    NCBI Gene ID: 255308
    UniProt: Q2VIR3

  • Chr Location
    12p13.2; chr12:10505602-10523135 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human EIF2S3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    880
  • Tissues
    20
  • cDNA Data
    337
  • Literature Summary
    5
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 26905 NCBI Gene Model | MGI Sequence Detail 23943 C57BL/6J ±  kb
transcript NM_012010 RefSeq | MGI Sequence Detail 3587 C57BL/6  
polypeptide Q9Z0N1 UniProt | EBI | MGI Sequence Detail 472 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    8 Sequences
  • Protein Ontology
    PR:000026090 eukaryotic translation initiation factor 2 subunit 3, X-linked
    (term hierarchy)
  • EC
    3.6.5.3
  • InterPro Domains
    IPR050543 Eukaryotic Initiation Factor 2 Gamma Subunit
    IPR015256 Initiation factor eIF2 gamma, C-terminal
    IPR044127 Initiation factor eIF2 gamma, domain 2
    IPR044128 Initiation factor eIF2 gamma, GTP-binding domain
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR000795 Translational (tr)-type GTP-binding domain
    IPR009001 Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal
    IPR004161 Translation elongation factor EFTu-like, domain 2
    IPR009000 Translation protein, beta-barrel domain superfamily
  • GlyGen
    Q9Z0N1 2 sites, 1 O-linked glycan (2 sites)
Molecular
Reagents
less
  • All nucleic 342
    Genomic 1
    cDNA 337
    Primer pair 2
    Other 2

    Microarray probesets 6
Other
Accession IDs
less
MGI:2147826, MGI:2147862, MGI:3035384
References
more
  • Summaries
    All 42
    Developmental Gene Expression 5
    Gene Ontology 8
    Phenotypes 6
  • Earliest
    J:50115 Ehrmann IE, et al., Characterization of genes encoding translation initiation factor eIF-2gamma in mouse and human: sex chromosome localization, escape from X-inactivation and evolution. Hum Mol Genet. 1998 Oct;7(11):1725-37
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory