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Med14 Gene Detail
Summary
  • Symbol
    Med14
  • Name
    mediator complex subunit 14
  • Synonyms
    9930001L01Rik, Crsp2, ENSMUSG00000073278, LOC270579, ORF1, Trap170
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349442
    NCBI Gene: 26896
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:12541608-12628312 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 7.52 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1735 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1349442
 protein coding gene ChrX:12541607-12628813 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035569
 protein coding gene ChrX:7500334-7588647 (-)
A/J MGP_AJ_G0035547
 protein coding gene ChrX:7602378-7691792 (-)
AKR/J MGP_AKRJ_G0035479
 protein coding gene ChrX:7823662-7914850 (-)
BALB/cJ MGP_BALBcJ_G0035540
 protein coding gene ChrX:7454477-7542106 (-)
C3H/HeJ MGP_C3HHeJ_G0035256
 protein coding gene ChrX:7602214-7691588 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036069
 protein coding gene ChrX:7690503-7781112 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032939
 protein coding gene ChrX:6526054-6607740 (-)
CAST/EiJ MGP_CASTEiJ_G0034548
 protein coding gene ChrX:7349749-7441871 (-)
CBA/J MGP_CBAJ_G0035225
 protein coding gene ChrX:8085389-8174994 (-)
DBA/2J MGP_DBA2J_G0035378
 protein coding gene ChrX:7442376-7530687 (-)
FVB/NJ MGP_FVBNJ_G0035325
 protein coding gene ChrX:7275733-7367476 (-)
LP/J MGP_LPJ_G0035460
 protein coding gene ChrX:7687826-7775624 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035368
 protein coding gene ChrX:8007003-8098751 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036081
 protein coding gene ChrX:7424109-7512540 (-)
PWK/PhJ MGP_PWKPhJ_G0034249
 protein coding gene ChrX:6948997-7037776 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034090
 protein coding gene ChrX:7515137-7606289 (-)
WSB/EiJ MGP_WSBEiJ_G0034684
 protein coding gene ChrX:7492704-7580207 (-)



Homology
more
  • Human Ortholog
    MED14, mediator complex subunit 14
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MED14, mediator complex subunit 14
  • Synonyms
    CRSP150, CRSP2, CSRP, CXorf4, DRIP150, EXLM1, RGR1, TRAP170
  • Links
    NCBI Gene ID: 9282
    neXtProt AC: NX_O60244
    UniProt: O60244

  • Chr Location
    Xp11.4; chrX:40648305-40736159 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    6 images
    6 phenotype references
Male chimeras hemizygous for a gene trapped allele appear normal at E10.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    944
  • Tissues
    156
  • cDNA Data
    22
  • Literature Summary
    6
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000064127 Ensembl Gene Model | MGI Sequence Detail 86705 C57BL/6J ±  kb
transcript ENSMUST00000096495 Ensembl | MGI Sequence Detail 6963 Not Applicable  
polypeptide ENSMUSP00000094239 Ensembl | MGI Sequence Detail 1459 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 25
    Genomic 1
    cDNA 22
    Primer pair 2

    Microarray probesets 7
Other
Accession IDs
less
MGI:2147974, MGI:2685487, MGI:3641973
References
more
  • Summaries
    All 44
    Developmental Gene Expression 6
    Gene Ontology 8
    Phenotypes 6
  • Earliest
    J:58086 Takada S, et al., Detection and cloning of an X-linked locus associated with a NotI site that is not methylated on mouse inactivated X chromosome by the RLGS-M method. Genomics. 1999 Oct 1;61(1):92-100
  • Latest
    J:347774 Kolonay DW, et al., Temporal regulation of the Mediator complex during muscle proliferation, differentiation, regeneration, aging, and disease. Front Cell Dev Biol. 2024;12:1331563
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory