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Ppp2r5e Gene Detail
Summary
  • Symbol
    Ppp2r5e
  • Name
    protein phosphatase 2, regulatory subunit B', epsilon
  • Synonyms
    4633401M22Rik, B56beta, protein phosphatase 2A subunit beta
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349473
    NCBI Gene: 26932
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:75497655-75643019 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 32.75 cM, cytoband D1
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2739 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1349473
 protein coding gene Chr12:75496237-75643064 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019848
 protein coding gene Chr12:75461656-75624046 (-)
A/J MGP_AJ_G0019806
 protein coding gene Chr12:72642175-72793169 (-)
AKR/J MGP_AKRJ_G0019781
 protein coding gene Chr12:74835203-74985317 (-)
BALB/cJ MGP_BALBcJ_G0019785
 protein coding gene Chr12:73108907-73255609 (-)
C3H/HeJ MGP_C3HHeJ_G0019591
 protein coding gene Chr12:75302757-75451530 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020237
 protein coding gene Chr12:77830276-77989655 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017855
 protein coding gene Chr12:69985269-70133634 (-)
CAST/EiJ MGP_CASTEiJ_G0019142
 protein coding gene Chr12:70085625-70238601 (-)
CBA/J MGP_CBAJ_G0019561
 protein coding gene Chr12:80815738-80981477 (-)
DBA/2J MGP_DBA2J_G0019677
 protein coding gene Chr12:72507565-72653318 (-)
FVB/NJ MGP_FVBNJ_G0019664
 protein coding gene Chr12:71329677-71476200 (-)
LP/J MGP_LPJ_G0019749
 protein coding gene Chr12:75480839-75633003 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019703
 protein coding gene Chr12:83884669-84039529 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020273
 protein coding gene Chr12:74316592-74466936 (-)
PWK/PhJ MGP_PWKPhJ_G0018908
 protein coding gene Chr12:66851612-66999284 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018702
 protein coding gene Chr12:68798120-68955366 (-)
WSB/EiJ MGP_WSBEiJ_G0019194
 protein coding gene Chr12:74906401-75061534 (-)



Homology
more
  • Human Ortholog
    PPP2R5E, protein phosphatase 2 regulatory subunit B'epsilon
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PPP2R5E, protein phosphatase 2 regulatory subunit B'epsilon
  • Synonyms
    B56E, B56epsilon
  • Links
    NCBI Gene ID: 5529
    neXtProt AC: NX_Q16537
    UniProt: Q16537

  • Chr Location
    14q23.2; chr14:63371364-63543377 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    727
  • Tissues
    21
  • cDNA Data
    18
  • Literature Summary
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021051 Ensembl Gene Model | MGI Sequence Detail 145365 C57BL/6J ±  kb
transcript ENSMUST00000021447 Ensembl | MGI Sequence Detail 4810 Not Applicable  
polypeptide ENSMUSP00000021447 Ensembl | MGI Sequence Detail 467 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000013147 serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform
    (term hierarchy)
  • InterPro Domains
    IPR011989 Armadillo-like helical
    IPR016024 Armadillo-type fold
    IPR002554 Protein phosphatase 2A, regulatory B subunit, B56
  • GlyGen
    Q61151 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 21
    cDNA 20
    Primer pair 1

    Microarray probesets 9
Other
Accession IDs
less
MGI:1913952, MGI:2144826
References
more
  • Summaries
    All 46
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 15
  • Earliest
    J:55804 Okamoto K, et al., p53-dependent association between cyclin G and the B' subunit of protein phosphatase 2A. Mol Cell Biol. 1996 Nov;16(11):6593-602
  • Latest
    J:348684 Dyson JJ, et al., Growth arrest of PPP2R5C and PPP2R5D double knockout mice indicates a genetic interaction and conserved function for these PP2A B subunits. FASEB Bioadv. 2022 Apr;4(4):273-282
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory