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Ing1 Gene Detail
Summary
  • Symbol
    Ing1
  • Name
    inhibitor of growth family, member 1
  • Synonyms
    2610028J21Rik, mING1h, p33Ing1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349481
    NCBI Gene: 26356
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:11605762-11613251 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 5.73 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    184 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1349481
 protein coding gene Chr8:11605571-11613251 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033356
 protein coding gene Chr8:8772867-8781182 (+)
A/J MGP_AJ_G0033336
 protein coding gene Chr8:8477152-8483891 (+)
AKR/J MGP_AKRJ_G0033267
 protein coding gene Chr8:8727975-8737222 (+)
BALB/cJ MGP_BALBcJ_G0033337
 protein coding gene Chr8:8619530-8627399 (+)
C3H/HeJ MGP_C3HHeJ_G0033050
 protein coding gene Chr8:8898431-8906533 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033849
 protein coding gene Chr8:9122387-9131085 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030819
 protein coding gene Chr8:8005756-8014042 (+)
CAST/EiJ MGP_CASTEiJ_G0032372
 protein coding gene Chr8:8638624-8645849 (+)
CBA/J MGP_CBAJ_G0033023
 protein coding gene Chr8:9516445-9527023 (+)
DBA/2J MGP_DBA2J_G0033176
 protein coding gene Chr8:8457394-8464576 (+)
FVB/NJ MGP_FVBNJ_G0033125
 protein coding gene Chr8:8425580-8432655 (+)
LP/J MGP_LPJ_G0033270
 protein coding gene Chr8:8695878-8704791 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033159
 protein coding gene Chr8:9817311-9826046 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033866
 protein coding gene Chr8:8746294-8753970 (+)
PWK/PhJ MGP_PWKPhJ_G0032085
 protein coding gene Chr8:8449585-8456829 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031927
 protein coding gene Chr8:8659410-8666635 (+)
WSB/EiJ MGP_WSBEiJ_G0032488
 protein coding gene Chr8:8785857-8794825 (+)



Homology
more
  • Human Ortholog
    ING1, inhibitor of growth family member 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ING1, inhibitor of growth family member 1
  • Synonyms
    p24ING1c, p33, p33ING1, p33ING1b, p47, p47ING1a
  • Links
    NCBI Gene ID: 3621
    neXtProt AC: NX_Q9UK53
    UniProt: Q9UK53

  • Chr Location
    13q34; chr13:110712623-110723339 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human ING1 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 3 alleles in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display a slight decrease in body weight, moderately impaired maternal nurturing, increased sensitivity to gamma-irradiation, and increased incidence of B-cell derived lymphomas.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    835
  • Tissues
    79
  • cDNA Data
    19
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 26356 NCBI Gene Model | MGI Sequence Detail 7490 C57BL/6J ±  kb
    transcript NM_011919 RefSeq | MGI Sequence Detail 2433 C57BL/6  
    polypeptide Q9QXV3 UniProt | EBI | MGI Sequence Detail 279 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 27
      cDNA 20
      Primer pair 3
      Other 4

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1916494, MGI:2142397, MGI:2144914
    References
    more
    • Summaries
      All 60
      Developmental Gene Expression 8
      Gene Ontology 10
      Phenotypes 12
    • Earliest
      J:39291 Helbing CC, et al., A novel candidate tumor suppressor, ING1, is involved in the regulation of apoptosis. Cancer Res. 1997 Apr 1;57(7):1255-8
    • Latest
      J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory