Eloa MGI Mouse Gene Detail - MGI:1351315 - elongin A

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Eloa Gene Detail

Symbol

Eloa
Name

elongin A
Synonyms

Tceb3

Feature Type

protein coding gene
IDs

MGI:1351315
NCBI Gene: 27224
Alliance

gene page
Transcription Start Sites

5 TSS
Candidate for QTL

1 QTL

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Sequence Map

Chr4:135730681-135748960 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 68.34 cM, cytoband D3
Mapping Data

4 experiments

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SNPs within 2kb

488 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates	Select Strains
C57BL/6J	MGI_C57BL6J_1351315	protein coding gene	Chr4:135730679-135749074 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0028958	protein coding gene	Chr4:138502168-138522516 (-)
A/J	MGP_AJ_G0028917	protein coding gene	Chr4:132621628-132640077 (-)
AKR/J	MGP_AKRJ_G0028869	protein coding gene	Chr4:136457575-136476800 (-)
BALB/cJ	MGP_BALBcJ_G0028941	protein coding gene	Chr4:133292952-133313036 (-)
C3H/HeJ	MGP_C3HHeJ_G0028655	protein coding gene	Chr4:136733802-136753835 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0029382	protein coding gene	Chr4:143414717-143436790 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026653	protein coding gene	Chr4:125671993-125690611 (-)
CAST/EiJ	MGP_CASTEiJ_G0028087	protein coding gene	Chr4:134873111-134891660 (-)
CBA/J	MGP_CBAJ_G0028620	protein coding gene	Chr4:147361008-147381406 (-)
DBA/2J	MGP_DBA2J_G0028769	protein coding gene	Chr4:133053435-133071532 (-)
FVB/NJ	MGP_FVBNJ_G0028736	protein coding gene	Chr4:131974850-131997997 (-)
LP/J	MGP_LPJ_G0028868	protein coding gene	Chr4:138600456-138618019 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028762	protein coding gene	Chr4:151626532-151647644 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029420	protein coding gene	Chr4:136907716-136925719 (-)
PWK/PhJ	MGP_PWKPhJ_G0027807	protein coding gene	Chr4:129820959-129838786 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0027633	protein coding gene	Chr4:132724996-132746415 (-)
WSB/EiJ	MGP_WSBEiJ_G0028165	protein coding gene	Chr4:137080642-137100419 (-)

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Human Ortholog

ELOA, elongin A

Vertebrate Orthologs

7

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ELOA, elongin A
Synonyms

ELOA1, SIII, SIII p110, TCEB3, TCEB3A
Links

HGNC:11620

NCBI Gene ID: 6924

neXtProt AC: NX_Q14241

UniProt: Q14241
Chr Location

1p36.11; chr1:23743448-23762059 (+) GRCh38

Human Ortholog

ELOA2, elongin A2
Synonyms

HsT832, TCEB3B, TCEB3L
Links

HGNC:30771

NCBI Gene ID: 51224

neXtProt AC: NX_Q8IYF1

UniProt: Q8IYF1
Chr Location

18q21.1; chr18:47032527-47035621 (-) GRCh38

Human Ortholog

ELOA3DP, elongin A3 family member D, pseudogene
Synonyms

ELOA3D, ELOA3L2, TCEB3CL2
Links

HGNC:33511

NCBI Gene ID: 100506888
Chr Location

18

Human Ortholog

ELOA3P, elongin A3, pseudogene
Synonyms

ELOA3, ELOA3A, ELOA3AP, HsT829, TCEB3C, TCEB3L2
Links

HGNC:24617

NCBI Gene ID: 162699
Chr Location

18q21.1; chr18:47028021-47030461 (-) GRCh38

MGI Vertebrate Homology

Eloa stringent orthology
4 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: ELOA, ELOA2, ELOA3DP, ELOA3P
Gene Tree

Eloa

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Phenotype Summary

22 phenotypes from 2 alleles in 2 genetic backgrounds
3 phenotypes from multigenic genotypes
12 phenotype references

Phenotype Overview

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

2
Endonuclease-mediated

1
Gene trapped

2
Targeted

3
Genomic Mutations

3 involving Eloa
Incidental Mutations

APF
Find Mice (IMSR)

22 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Embryos homozygous for a knock-out allele are severely growth retarded, exhibit a wide range of developmental anomalies and die between E10.5 and E12.5, most likely due to massive apoptosis while mutant MEFs show increased apoptosis and senescence-like growth defects.

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All GO Annotations

9
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

736
Tissues

28
cDNA Data

23
Literature Summary

3

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase eloa

ZFIN eloa

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All Sequences

48
RefSeq

2
UniProt

1
CCDS

CCDS18798.1

Ensembl

ENSMUSG00000028668 (Evidence)
NCBI Gene

27224

Representative Sequences				Length	Strain/Species	Flank
	genomic	27224	NCBI Gene Model \| MGI Sequence Detail	18280	C57BL/6J	± kb
	transcript	NM_013736	RefSeq \| MGI Sequence Detail	4592	C57BL/6
	polypeptide	Q8CB77	UniProt \| EBI \| MGI Sequence Detail	773	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000016170 elongin-A

(term hierarchy)
InterPro Domains

IPR051870 Elongin-A domain-containing protein

IPR001810 F-box domain

IPR010684 RNA polymerase II transcription factor SIII, subunit A

IPR035441 TFIIS/LEDGF domain superfamily

IPR003617 Transcription elongation factor, TFIIS/CRSP70, N-terminal, sub-type

IPR017923 Transcription factor IIS, N-terminal

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All nucleic 25

Genomic 1

cDNA 23

Primer pair 1

Microarray probesets 5

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MGI:2140124

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Summaries

All 43

Developmental Gene Expression 3

Gene Ontology 5

Phenotypes 12
Earliest

J:58555 Aso T, et al., Structural organization and chromosome location of the mouse elongin A gene (Tceb3). Cytogenet Cell Genet. 1999;86(3-4):259-62
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Eloa:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr44025	Chr4:135749033-135749047 (-)	-80 bp
Tssr44024	Chr4:135748996-135749005 (-)	-41 bp
Tssr44023	Chr4:135748940-135748976 (-)	2 bp
Tssr44022	Chr4:135737845-135737856 (-)	11,109 bp
Tssr44021	Chr4:135732549-135732553 (-)	16,409 bp

Eloa is Candidate Gene for:

QTL	Genetic Location*	Genome Location (GRCm39)	Reference	QTL Note
Cdcs9	Chr4, 75.67 cM	Chr4:142230872-142230960	J:109420	Microarray analysis was used to identify candidate genes for colitis susceptibility QTLs. Messenger RNA was analyzed for expression differences between colitis susceptible inbred strain C3H/HeJBir-Il10 and colitis resistant inbred strain C57BL/6J-Il10. Capn3 (67.2 cM) on mouse Chromosome 2 is upregulated 1.5- to 2-fold in C3H/HeJBir-Il10 animals. This candidate gene maps to the Cdcs3 (cytokine deficiency colitis susceptibility 3) interval centered near 65 cM. Gbp1 (67.4 cM) on mouse Chromosome 3 is upregulated over 15-fold in C3H/HeJBir-Il10 animals. This candidate gene is known to be polymorphic between C3H/HeJBir and C57BL/6J and exhibits expression differences in these parental wild type strains. Gbp1 maps to the Cdcs1 (cytokine deficiency colitis susceptibility 1) interval centered near 62 cM. Adh1 at 71.2 cM and Bglap2 at 42.6 cM also map to the same QTL interval. Adh1 is upregulated 1.5- to 2-fold, and Blgap2 is upregulated 2- to 5-fold, in C3H/HeJBir-Il10animals. Pla2g2a (68 cM) on mouse Chromosome 4 is upregulated over 15-fold in C3H/HeJBir-Il10 animals. This candidate gene is known to be polymorphic between C3H/HeJBir and C57BL/6J and exhibits expression differences in these parental wild typestrains. Pla2g2a maps to the Cdcs9 (cytokine deficiency colitis susceptibility 9) interval centered near 71 cM. Moreover, C57BL/6J animals are known to carry the frameshift mutation Pla2g2a resulting in multiple intestinal neoplasia. The human ortholog PLA2G2A maps near a irritable bowel disorder (IBD) susceptibility locus named IBD7. Gnb1 (79.4 cM) also maps to the Cdcs9 QTL interval and is upregulated 2- to 5-fold in C57BL/6J-Il10 animals. Errfi1 (formerly 1300002F13Rik) and Tceb3 also map to the Cdcs9 interval and are upregulated 1.5- to 2-fold in C57BL/6J-Il10 animals. Areg (51 cM) on mouse Chromosome 5 maps near the Cdcs10 QTL interval centered around 45 cM. This candidate gene is upregulated 1.5- to 2-fold in C57BL/6J-Il10 animals. Mtmr7 maps to mouse Chromosome 8 near the Cdcs4 interval centered around 21 cM. This candidate gene is upregulated over 15-fold in C57BL/6J-Il10 animals. Cd14 (31 cM) on mouse Chromosome 18 is upregulated 5- to 15-fold in C3H/HeJBir-Il10 animals. CD14 also exhibits expression differences in parental wild type strains C3H/HeJBir and C57BL/6J. This candidate gene maps to the Cdcs6 (cytokine deficiency colitis susceptibility 6) interval centered near 41 cM. The human ortholog CD14 maps near a human irritable bowel disorder (IBD) susceptibility locus named IBD5. Glo1 (16 cM) and Ly6g6c on mouse Chromosome 17 are upregulated 2- to 5-fold in C57BL/6J-Il10 animals. This candidate gene maps to the Cdcs5 (cytokine deficiency colitis susceptibility 5) interval centered near 19 cM. Hspa1a (18.9 cM) and Hspa1b (18.9 cM) also map to Cdcs5 and are upregulated 1.5- to 2-fold in C57BL/6J-Il10 animals.

*cM position of peak correlated region/marker

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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