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Grm7 Gene Detail
Summary
  • Symbol
    Grm7
  • Name
    glutamate receptor, metabotropic 7
  • Synonyms
    6330570A01Rik, E130018M02Rik, Gpr1g, mGlu7a receptor, mGluR7
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351344
    NCBI Gene: 108073
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:110622542-111544191 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 51.19 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    27299 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351344
 protein coding gene Chr6:110622304-111544191 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031104
 protein coding gene Chr6:113009955-113969550 (+)
A/J MGP_AJ_G0031073
 protein coding gene Chr6:108718917-109638803 (+)
AKR/J MGP_AKRJ_G0031004
 protein coding gene Chr6:111643019-112586236 (+)
BALB/cJ MGP_BALBcJ_G0031084
 protein coding gene Chr6:108659432-109591041 (+)
C3H/HeJ MGP_C3HHeJ_G0030624
 protein coding gene Chr6:71730715-72671734 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031543
 protein coding gene Chr6:115988675-116987743 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028707
 protein coding gene Chr6:105817032-106684752 (+)
CAST/EiJ MGP_CASTEiJ_G0030191
 protein coding gene Chr6:112036905-112996874 (+)
CBA/J MGP_CBAJ_G0030770
 protein coding gene Chr6:120476276-121550443 (+)
DBA/2J MGP_DBA2J_G0030923
 protein coding gene Chr6:107812316-108750017 (+)
FVB/NJ MGP_FVBNJ_G0030877
 protein coding gene Chr6:106831611-107730213 (+)
LP/J MGP_LPJ_G0031003
 protein coding gene Chr6:113092655-114059795 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030911
 protein coding gene Chr6:124850785-125922065 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031570
 protein coding gene Chr6:111627195-112579969 (+)
PWK/PhJ MGP_PWKPhJ_G0029907
 protein coding gene Chr6:106744259-107662132 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029735
 protein coding gene Chr6:110383436-111362799 (+)
WSB/EiJ MGP_WSBEiJ_G0030275
 protein coding gene Chr6:112124701-112969014 (+)



Homology
more
  • Human Ortholog
    GRM7, glutamate metabotropic receptor 7
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GRM7, glutamate metabotropic receptor 7
  • Synonyms
    GLUR7, GPRC1G, MGLU7, MGLUR7, NEDSHBA, PPP1R87
  • Links
    NCBI Gene ID: 2917
    neXtProt AC: NX_Q14831
    UniProt: Q14831

  • Chr Location
    3p26.1; chr3:6770001-7741533 (+)  GRCh38
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    9 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 5 alleles in 5 genetic backgrounds
    87 phenotypes from multigenic genotypes
    255 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Nullizygous mice exhibit seizures and deficits in ejaculation, fear response and conditioned taste aversion. Homozygotes for a knock-in allele show impaired spatial working memory and higher susceptibility to pentylenetetrazol. Homozygotes for a reporter allele show impaired coordination and higher susceptibility to metrazol.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    73
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    855
  • Tissues
    92
  • cDNA Data
    17
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000056755 Ensembl Gene Model | MGI Sequence Detail 921650 C57BL/6J ±  kb
    transcript ENSMUST00000071076 Ensembl | MGI Sequence Detail 3127 Not Applicable  
    polypeptide ENSMUSP00000064404 Ensembl | MGI Sequence Detail 922 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      9 Sequences
    • Protein Ontology
      PR:000008269 metabotropic glutamate receptor 7
      (term hierarchy)
    • InterPro Domains
      IPR000337 GPCR, family 3
      IPR017979 GPCR, family 3, conserved site
      IPR017978 GPCR family 3, C-terminal
      IPR000162 GPCR, family 3, metabotropic glutamate receptor
      IPR001883 GPCR, family 3, metabotropic glutamate receptor 7
      IPR011500 GPCR, family 3, nine cysteines domain
      IPR038550 GPCR, family 3, nine cysteines domain superfamily
      IPR050726 Metabotropic Glutamate Receptor
      IPR028082 Periplasmic binding protein-like I
      IPR001828 Receptor, ligand binding region
    • GlyGen
      Q68ED2 5 sites, 3 N-linked glycans (3 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 17
      Primer pair 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-10270, MGI:2141737, MGI:2442018, MGI:2676918, MGI:95831
    References
    more
    • Summaries
      All 303
      Developmental Gene Expression 8
      Diseases 9
      Gene Ontology 14
      Phenotypes 255
    • Earliest
      J:39076 Kaupmann K, et al., Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors [see comments]. Nature. 1997 Mar 20;386(6622):239-46
    • Latest
      J:355146 Rhee J, et al., Improved therapeutic approach for spinal muscular atrophy via ubiquitination-resistant survival motor neuron variant. J Cachexia Sarcopenia Muscle. 2024 Aug;15(4):1404-1417
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory