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Nufip1 Gene Detail
Summary
  • Symbol
    Nufip1
  • Name
    nuclear FMR1 interacting protein 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351474
    NCBI Gene: 27275
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:76348337-76372527 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 40.35 cM, cytoband D2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    714 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351474
 protein coding gene Chr14:76348331-76374819 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021579
 protein coding gene Chr14:71016670-71043525 (+)
A/J MGP_AJ_G0021537
 protein coding gene Chr14:69378467-69404955 (+)
AKR/J MGP_AKRJ_G0021514
 protein coding gene Chr14:71449496-71476550 (+)
BALB/cJ MGP_BALBcJ_G0021544
 protein coding gene Chr14:69170503-69196991 (+)
C3H/HeJ MGP_C3HHeJ_G0021321
 protein coding gene Chr14:71170353-71197501 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021984
 protein coding gene Chr14:74112886-74139374 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019522
 protein coding gene Chr14:66989677-67018244 (+)
CAST/EiJ MGP_CASTEiJ_G0020838
 protein coding gene Chr14:67864541-67892340 (+)
CBA/J MGP_CBAJ_G0021289
 protein coding gene Chr14:76493563-76521391 (+)
DBA/2J MGP_DBA2J_G0021412
 protein coding gene Chr14:68782217-68808690 (+)
FVB/NJ MGP_FVBNJ_G0021390
 protein coding gene Chr14:68123720-68150203 (+)
LP/J MGP_LPJ_G0021482
 protein coding gene Chr14:72158907-72185445 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021417
 protein coding gene Chr14:75194942-75221408 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022007
 protein coding gene Chr14:70731127-70757545 (+)
PWK/PhJ MGP_PWKPhJ_G0020581
 protein coding gene Chr14:65527706-65554500 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020418
 protein coding gene Chr14:66687108-66714782 (+)
WSB/EiJ MGP_WSBEiJ_G0020891
 protein coding gene Chr14:71066615-71093100 (+)



Homology
more
  • Human Ortholog
    NUFIP1, nuclear FMR1 interacting protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NUFIP1, nuclear FMR1 interacting protein 1
  • Synonyms
    bA540M5.1, NUFIP, Rsa1
  • Links
    NCBI Gene ID: 26747
    neXtProt AC: NX_Q9UHK0
    UniProt: Q9UHK0

  • Chr Location
    13q14.12; chr13:44939249-44989471 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional allele activated in fibroblasts exhibit reduced proliferation of implanted tumor cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    37
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    716
  • Tissues
    9
  • cDNA Data
    60
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 27275 NCBI Gene Model | MGI Sequence Detail 24191 C57BL/6J ±  kb
transcript NR_188811 RefSeq | MGI Sequence Detail 1854 C57BL/6  
polypeptide Q9QXX8 UniProt | EBI | MGI Sequence Detail 484 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 61
    cDNA 60
    Primer pair 1

    Microarray probesets 4
References
more
  • Summaries
    All 40
    Developmental Gene Expression 2
    Gene Ontology 7
    Phenotypes 12
  • Earliest
    J:58813 Bardoni B, et al., A novel RNA-binding nuclear protein that interacts with the fragile X mental retardation (FMR1) protein. Hum Mol Genet. 1999 Dec;8(13):2557-66
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory