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Npas3 Gene Detail
Summary
  • Symbol
    Npas3
  • Name
    neuronal PAS domain protein 3
  • Synonyms
    4930423H22Rik, bHLHe12
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351610
    NCBI Gene: 27386
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:53294940-54118958 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 22.31 cM, cytoband C1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    21412 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351610
 protein coding gene Chr12:53294874-54118958 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019734
 protein coding gene Chr12:52111257-52956915 (+)
A/J MGP_AJ_G0019696
 protein coding gene Chr12:50268660-51102180 (+)
AKR/J MGP_AKRJ_G0019667
 protein coding gene Chr12:51764228-52616504 (+)
BALB/cJ MGP_BALBcJ_G0019674
 protein coding gene Chr12:50545365-51381837 (+)
C3H/HeJ MGP_C3HHeJ_G0019477
 protein coding gene Chr12:51872562-52726909 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020122
 protein coding gene Chr12:53706343-54567208 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017745
 protein coding gene Chr12:48593574-49419521 (+)
CAST/EiJ MGP_CASTEiJ_G0019030
 protein coding gene Chr12:46923249-47776107 (+)
CBA/J MGP_CBAJ_G0019449
 protein coding gene Chr12:55551867-56443941 (+)
DBA/2J MGP_DBA2J_G0019563
 protein coding gene Chr12:50131382-50959757 (+)
FVB/NJ MGP_FVBNJ_G0019552
 protein coding gene Chr12:49555512-50382873 (+)
LP/J MGP_LPJ_G0019635
 protein coding gene Chr12:52180496-53028611 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019588
 protein coding gene Chr12:57226289-58091876 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020160
 protein coding gene Chr12:51281081-52126123 (+)
PWK/PhJ MGP_PWKPhJ_G0018797
 protein coding gene Chr12:44697422-45530300 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018591
 protein coding gene Chr12:45858689-46714817 (+)
WSB/EiJ MGP_WSBEiJ_G0019081
 protein coding gene Chr12:51746867-52595510 (+)



Homology
more
  • Human Ortholog
    NPAS3, neuronal PAS domain protein 3
  • Vertebrate Orthologs
    1
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NPAS3, neuronal PAS domain protein 3
  • Synonyms
    bHLHe12, MOP6, PASD6
  • Links
    NCBI Gene ID: 64067
    neXtProt AC: NX_Q8IXF0
    UniProt: Q8IXF0

  • Chr Location
    14q13.1; chr14:32934396-33820863 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    43 phenotypes from 4 alleles in 4 genetic backgrounds
    8 phenotypes from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for some knock-out alleles exhibit abnormal behavior and nervous system morphology. Mice homozygous for another knock-out allele exhibit defective lung branching morphogenesis and die shortly after birth.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    930
  • Tissues
    157
  • cDNA Data
    14
  • Literature Summary
    15
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021010 Ensembl Gene Model | MGI Sequence Detail 824019 C57BL/6J ±  kb
    transcript ENSMUST00000101432 Ensembl | MGI Sequence Detail 5879 Not Applicable  
    polypeptide ENSMUSP00000098975 Ensembl | MGI Sequence Detail 925 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 14
      Primer pair 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1918894
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 15
      Gene Ontology 7
      Phenotypes 17
    • Earliest
      J:24330 Cserjesi P, et al., Scleraxis: a basic helix-loop-helix protein that prefigures skeletal formation during mouse embryogenesis. Development. 1995 Apr;121(4):1099-110
    • Latest
      J:357284 Lo Giudice Q, et al., Developmental emergence of first- and higher-order thalamic neuron molecular identities. Development. 2024 Sep 15;151(18)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory