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Exoc6 Gene Detail
Summary
  • Symbol
    Exoc6
  • Name
    exocyst complex component 6
  • Synonyms
    4833405E05Rik, hbd, msec15, Sec15, Sec15l1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351611
    NCBI Gene: 107371
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:37525181-37672499 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 32.32 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4296 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351611
 protein coding gene Chr19:37509327-37672507 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025082
 protein coding gene Chr19:36538976-36678112 (+)
A/J MGP_AJ_G0025058
 protein coding gene Chr19:34769755-34901617 (+)
AKR/J MGP_AKRJ_G0025026
 protein coding gene Chr19:35964271-36095411 (+)
BALB/cJ MGP_BALBcJ_G0025056
 protein coding gene Chr19:34858547-34989389 (+)
C3H/HeJ MGP_C3HHeJ_G0024815
 protein coding gene Chr19:36017514-36158117 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025497
 protein coding gene Chr19:37609626-37746089 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022916
 protein coding gene Chr19:34135440-34263123 (+)
CAST/EiJ MGP_CASTEiJ_G0024282
 protein coding gene Chr19:35866369-36011645 (+)
CBA/J MGP_CBAJ_G0024792
 protein coding gene Chr19:39342480-39491330 (+)
DBA/2J MGP_DBA2J_G0024924
 protein coding gene Chr19:34623023-34755461 (+)
FVB/NJ MGP_FVBNJ_G0024885
 protein coding gene Chr19:34432521-34563178 (+)
LP/J MGP_LPJ_G0025010
 protein coding gene Chr19:36636849-36779436 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024916
 protein coding gene Chr19:39155994-39299965 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025555
 protein coding gene Chr19:36041605-36177211 (+)
PWK/PhJ MGP_PWKPhJ_G0024034
 protein coding gene Chr19:34476099-34608286 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023834
 protein coding gene Chr19:34885663-35025111 (+)
WSB/EiJ MGP_WSBEiJ_G0024349
 protein coding gene Chr19:36133009-36265140 (+)



Homology
more
  • Human Ortholog
    EXOC6, exocyst complex component 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EXOC6, exocyst complex component 6
  • Synonyms
    EXOC6A, SEC15, SEC15L, SEC15L1, SEC15L3, Sec15p
  • Links
    NCBI Gene ID: 54536
    neXtProt AC: NX_Q8TAG9
    UniProt: Q8TAG9

  • Chr Location
    10q23.33; chr10:92826831-93059493 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    31 phenotypes from 2 alleles in 4 genetic backgrounds
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a spontaneous mutation exhibit severe microcytic anemia, erythrocyte hyperchromia, and markedly increased levels of red cell protoporphyrin.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    840
  • Tissues
    19
  • cDNA Data
    49
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 107371 NCBI Gene Model | MGI Sequence Detail 147319 C57BL/6J ±  kb
    transcript NM_175353 RefSeq | MGI Sequence Detail 2737 ZRU/MplStud  
    polypeptide Q8R313 UniProt | EBI | MGI Sequence Detail 802 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000007253 exocyst complex component 6
      (term hierarchy)
    • InterPro Domains
      IPR042044 EXOC6/PINT-1/Sec15/Tip20, C-terminal, domain 2
      IPR007225 Exocyst complex component EXOC6/Sec15
      IPR042045 Exocyst complex component EXOC6/Sec15, C-terminal, domain 1
      IPR048359 Exocyst complex component EXOC6/Sec15, N-terminal domain
      IPR046361 Exocyst complex subunit EXOC6/Sec15, C-terminal
    Molecular
    Reagents
    less
    • All nucleic 51
      Genomic 2
      cDNA 49

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-10640, MGI:2147727, MGI:96028
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 3
      Gene Ontology 6
      Phenotypes 22
    • Earliest
      J:5208 Scheufler H, [An additional house mouse mutant with anemia (hemoglobin deficiency)]. Z Versuchstierkd. 1969;11(5):348-53
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory