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Dnajb9 Gene Detail
Summary
  • Symbol
    Dnajb9
  • Name
    DnaJ heat shock protein family (Hsp40) member B9
  • Synonyms
    ERdj4, Mdg1, mDj7, microvascular endothelial differentiation gene
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351618
    NCBI Gene: 27362
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:44252680-44256851 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 20.71 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    166 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351618
 protein coding gene Chr12:44252342-44257109 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019710
 protein coding gene Chr12:42773071-42777242 (-)
A/J MGP_AJ_G0019674
 protein coding gene Chr12:41251183-41256563 (-)
AKR/J MGP_AKRJ_G0019645
 protein coding gene Chr12:42570310-42574481 (-)
BALB/cJ MGP_BALBcJ_G0019652
 protein coding gene Chr12:41549415-41553594 (-)
C3H/HeJ MGP_C3HHeJ_G0019456
 protein coding gene Chr12:42537614-42541785 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020099
 protein coding gene Chr12:44041413-44045584 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017724
 protein coding gene Chr12:40268934-40273158 (-)
CAST/EiJ MGP_CASTEiJ_G0019009
 protein coding gene Chr12:37697451-37701753 (-)
CBA/J MGP_CBAJ_G0019428
 protein coding gene Chr12:45507129-45511300 (-)
DBA/2J MGP_DBA2J_G0019541
 protein coding gene Chr12:41137855-41142027 (-)
FVB/NJ MGP_FVBNJ_G0019530
 protein coding gene Chr12:40662137-40666308 (-)
LP/J MGP_LPJ_G0019611
 protein coding gene Chr12:42741578-42745749 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019566
 protein coding gene Chr12:46198259-46202650 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020139
 protein coding gene Chr12:42153088-42157259 (-)
PWK/PhJ MGP_PWKPhJ_G0018776
 protein coding gene Chr12:35806134-35810697 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018566
 protein coding gene Chr12:36752997-36757167 (-)
WSB/EiJ MGP_WSBEiJ_G0019059
 protein coding gene Chr12:42454388-42460646 (-)



Homology
more
  • Human Ortholog
    DNAJB9, DnaJ heat shock protein family (Hsp40) member B9
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DNAJB9, DnaJ heat shock protein family (Hsp40) member B9
  • Synonyms
    ERdj4, MDG-1, MDG1, MST049, MSTP049
  • Links
    NCBI Gene ID: 4189
    neXtProt AC: NX_Q9UBS3
    UniProt: Q9UBS3

  • Chr Location
    7q31; chr7:108569867-108574850 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 1 allele in 3 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a hypomorphic allele show perinatal death, reduced birth size and liver glycogen levels, and hypoglycemia. Surviving adults show elevated ER stress in MEFs, lung, kidney, salivary gland and in pancreas, associated with beta cell loss, hypoinsulinemia, and glucose intolerance.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    807
  • Tissues
    97
  • cDNA Data
    14
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 27362 NCBI Gene Model | MGI Sequence Detail 4172 C57BL/6J ±  kb
    transcript NM_013760 RefSeq | MGI Sequence Detail 1865 C57BL/6  
    polypeptide Q9QYI6 UniProt | EBI | MGI Sequence Detail 222 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 15
      Primer pair 2
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2144721, MGI:2144746, MGI:2144747, MGI:2145046
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 6
      Gene Ontology 9
      Phenotypes 9
    • Earliest
      J:67228 Ohtsuka K, et al., Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature. Cell Stress Chaperones. 2000 Apr;5(2):98-112
    • Latest
      J:344311 Yan W, et al., Loss of Mptx2 alters bacteria composition and intestinal homeostasis potentially by impairing autophagy. Commun Biol. 2024 Jan 13;7(1):94
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory