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Pign Gene Detail
Summary
  • Symbol
    Pign
  • Name
    phosphatidylinositol glycan anchor biosynthesis, class N
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351629
    NCBI Gene: 27392
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:105446147-105591402 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 49.63 cM, cytoband D
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3052 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351629
 protein coding gene Chr1:105446147-105591466 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016366
 protein coding gene Chr1:107622357-107771758 (-)
A/J MGP_AJ_G0016350
 protein coding gene Chr1:103894692-104023132 (-)
AKR/J MGP_AKRJ_G0016310
 protein coding gene Chr1:106735285-106873823 (-)
BALB/cJ MGP_BALBcJ_G0016306
 protein coding gene Chr1:103978409-104114664 (-)
C3H/HeJ MGP_C3HHeJ_G0016133
 protein coding gene Chr1:107160363-107311299 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016765
 protein coding gene Chr1:111778541-111923745 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014483
 protein coding gene Chr1:98245785-98374177 (-)
CAST/EiJ MGP_CASTEiJ_G0015715
 protein coding gene Chr1:106074728-106217428 (-)
CBA/J MGP_CBAJ_G0016106
 protein coding gene Chr1:115574626-115719515 (-)
DBA/2J MGP_DBA2J_G0016211
 protein coding gene Chr1:102948707-103086435 (-)
FVB/NJ MGP_FVBNJ_G0016212
 protein coding gene Chr1:101893805-102025440 (-)
LP/J MGP_LPJ_G0016285
 protein coding gene Chr1:108902081-109047599 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016238
 protein coding gene Chr1:119995249-120181844 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016804
 protein coding gene Chr1:106808412-106952843 (-)
PWK/PhJ MGP_PWKPhJ_G0015502
 protein coding gene Chr1:101997249-102127759 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015287
 protein coding gene Chr1:105488116-105613393 (-)
WSB/EiJ MGP_WSBEiJ_G0015778
 protein coding gene Chr1:106650552-106789958 (-)



Homology
more
  • Human Ortholog
    PIGN, phosphatidylinositol glycan anchor biosynthesis class N
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PIGN, phosphatidylinositol glycan anchor biosynthesis class N
  • Synonyms
    MCAHS, MCAHS1, MCD4, MDC4, PIG-N
  • Links
    NCBI Gene ID: 23556
    neXtProt AC: NX_O95427
    UniProt: O95427

  • Chr Location
    18q21.33; chr18:61905255-62187118 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Pign mouse models; 1 with human PIGN associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    40 phenotypes from 2 alleles in 4 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced allele exhibit abnormal gastrulation, forebrain hypoplasia, coloboma, and microphthalmia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    843
  • Tissues
    123
  • cDNA Data
    59
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000056536 Ensembl Gene Model | MGI Sequence Detail 145256 C57BL/6J ±  kb
    transcript ENSMUST00000186485 Ensembl | MGI Sequence Detail 6759 Not Applicable  
    polypeptide ENSMUSP00000139638 Ensembl | MGI Sequence Detail 931 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000012701 GPI ethanolamine phosphate transferase 1
      (term hierarchy)
    • EC
      2.-.-.-
    • InterPro Domains
      IPR017850 Alkaline-phosphatase-like, core domain superfamily
      IPR007070 GPI ethanolamine phosphate transferase 1
      IPR017852 GPI ethanolamine phosphate transferase 1, C-terminal
      IPR037671 GPI ethanolamine phosphate transferase 1, N-terminal
      IPR002591 Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase
    • GlyGen
      Q9R1S3 5 sites, 2 N-linked glycans (3 sites)
    Molecular
    Reagents
    less
    • All nucleic 60
      cDNA 60

      Microarray probesets 6
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 6
      Phenotypes 13
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory