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Ip6k1 Gene Detail
Summary
  • Symbol
    Ip6k1
  • Name
    inositol hexaphosphate kinase 1
  • Synonyms
    1200016D08Rik, Ihpk1, InsP6, InsP6k1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351633
    NCBI Gene: 27399
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:107879847-107925981 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 59.07 cM, cytoband F2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    791 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351633
 protein coding gene Chr9:107879700-107925981 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035281
 protein coding gene Chr9:109918815-109973375 (+)
A/J MGP_AJ_G0035260
 protein coding gene Chr9:105906569-105953901 (+)
AKR/J MGP_AKRJ_G0035192
 protein coding gene Chr9:108547516-108597251 (+)
BALB/cJ MGP_BALBcJ_G0035254
 protein coding gene Chr9:105578488-105650265 (+)
C3H/HeJ MGP_C3HHeJ_G0034964
 protein coding gene Chr9:108944698-108995917 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035774
 protein coding gene Chr9:112892660-112947441 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032672
 protein coding gene Chr9:103339640-103388398 (+)
CAST/EiJ MGP_CASTEiJ_G0034275
 protein coding gene Chr9:108902326-108954756 (+)
CBA/J MGP_CBAJ_G0034932
 protein coding gene Chr9:116889130-116945006 (+)
DBA/2J MGP_DBA2J_G0035093
 protein coding gene Chr9:105363178-105409009 (+)
FVB/NJ MGP_FVBNJ_G0035041
 protein coding gene Chr9:104126901-104176615 (+)
LP/J MGP_LPJ_G0035169
 protein coding gene Chr9:110113259-110164409 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035080
 protein coding gene Chr9:118482726-118531887 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035795
 protein coding gene Chr9:108825894-108876543 (+)
PWK/PhJ MGP_PWKPhJ_G0033982
 protein coding gene Chr9:105683501-105730861 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033817
 protein coding gene Chr9:108890383-108937254 (+)
WSB/EiJ MGP_WSBEiJ_G0034396
 protein coding gene Chr9:108705183-108754964 (+)



Homology
more
  • Human Ortholog
    IP6K1, inositol hexakisphosphate kinase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IP6K1, inositol hexakisphosphate kinase 1
  • Synonyms
    IHPK1, PiUS
  • Links
    NCBI Gene ID: 9807
    neXtProt AC: NX_Q92551
    UniProt: Q92551

  • Chr Location
    3p21.31; chr3:49724294-49786542 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 3 alleles in 3 genetic backgrounds
    1 images
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in impaired glucose tolerance, decreased insulin levels, bilateral epididymal aspermia, and testicular degeneration in males. Homozygous KO also increases presynaptic neurotransmitter release in the hippocampus.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    808
  • Tissues
    97
  • cDNA Data
    219
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 27399 NCBI Gene Model | MGI Sequence Detail 46135 C57BL/6J ±  kb
    transcript NM_013785 RefSeq | MGI Sequence Detail 4429 C57BL/6  
    polypeptide Q6PD10 UniProt | EBI | MGI Sequence Detail 433 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 219
      cDNA 219

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:1914851, MGI:2143219
    References
    more
    • Summaries
      All 60
      Developmental Gene Expression 3
      Gene Ontology 10
      Phenotypes 21
    • Earliest
      J:58528 Saiardi A, et al., Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases. Curr Biol. 1999 Nov 18;9(22):1323-6
    • Latest
      J:345668 Jin H, et al., Deleting IP6K1 stabilizes neuronal sodium-potassium pumps and suppresses excitability. Mol Brain. 2024 Feb 13;17(1):8
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory