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Magel2 Gene Detail
Summary
  • Symbol
    Magel2
  • Name
    MAGE family member L2
  • Synonyms
    Mage-l2, NDNL1, nM15, ns7
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351648
    NCBI Gene: 27385
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:62026758-62031388 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 34.37 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    139 from dbSNP Build 142
  • Strain Annotations
    17
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351648
 protein coding gene Chr7:62026727-62031388 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032327
 protein coding gene Chr7:63459295-63463956 (+)
A/J MGP_AJ_G0032306
 protein coding gene Chr7:62252705-62257342 (+)
AKR/J MGP_AKRJ_G0032242
 protein coding gene Chr7:63573157-63577818 (+)
BALB/cJ MGP_BALBcJ_G0032318
 protein coding gene Chr7:61936282-61940940 (+)
C3H/HeJ MGP_C3HHeJ_G0032031
 protein coding gene Chr7:64180647-64185278 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032811
 protein coding gene Chr7:66222713-66227347 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029818
 protein coding gene Chr7:65283032-65287684 (+)
CAST/EiJ MGP_CASTEiJ_G0031360
 protein coding gene Chr7:54960501-54965141 (+)
CBA/J MGP_CBAJ_G0031997
 protein coding gene Chr7:68351513-68356174 (+)
DBA/2J MGP_DBA2J_G0032153
 protein coding gene Chr7:61078578-61083236 (+)
FVB/NJ MGP_FVBNJ_G0032107
 protein coding gene Chr7:61126664-61131322 (+)
LP/J no annotation
NOD/ShiLtJ MGP_NODShiLtJ_G0032144
 protein coding gene Chr7:68587174-68591835 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032828
 protein coding gene Chr7:62842275-62846934 (+)
PWK/PhJ MGP_PWKPhJ_G0031080
 protein coding gene Chr7:54055103-54059804 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030921
 protein coding gene Chr7:49965657-49970198 (+)
WSB/EiJ MGP_WSBEiJ_G0031478
 protein coding gene Chr7:63219385-63223956 (+)



Homology
more
  • Human Ortholog
    MAGEL2, MAGE family member L2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAGEL2, MAGE family member L2
  • Synonyms
    NDNL1, nM15, PWLS, SHFYNG
  • Links
    NCBI Gene ID: 54551
    neXtProt AC: NX_Q9UJ55
    UniProt: Q9UJ55

  • Chr Location
    15q11.2; chr15:23643549-23647867 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Magel2 mouse models; 1 with human MAGEL2 associations

Human Disease Mouse Models
      
IDs
 View 3 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    41 phenotypes from 3 alleles in 5 genetic backgrounds
    1 images
    58 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice heterozygous for a null allele that is inherited paternally exhibit some postnatal lethality, reduced male fertility, abnormal circadian rhythm, and hypoactivity. Mice heterozygous for another paternal knock-out allele exhibit 50% neonatal lethalityassociated with weak suckling activity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    972
  • Tissues
    111
  • cDNA Data
    38
  • Literature Summary
    33
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000056972 Ensembl Gene Model | MGI Sequence Detail 4631 C57BL/6J ±  kb
    transcript ENSMUST00000080403 Ensembl | MGI Sequence Detail 4631 Not Applicable  
    polypeptide ENSMUSP00000079265 Ensembl | MGI Sequence Detail 1284 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 47
      Genomic 2
      cDNA 38
      Primer pair 7

      Microarray probesets 3
    References
    more
    • Summaries
      All 117
      Developmental Gene Expression 33
      Diseases 6
      Gene Ontology 10
      Phenotypes 58
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory