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Slc14a1 Gene Detail
Summary
  • Symbol
    Slc14a1
  • Name
    solute carrier family 14 (urea transporter), member 1
  • Synonyms
    2610507K20Rik, 3021401A05Rik, UT-B
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351654
    NCBI Gene: 108052
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:78143306-78185334 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 52.49 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1494 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351654
 protein coding gene Chr18:78143306-78185334 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024583
 protein coding gene Chr18:78905789-78948796 (-)
A/J MGP_AJ_G0024550
 protein coding gene Chr18:75442267-75483579 (-)
AKR/J MGP_AKRJ_G0024521
 protein coding gene Chr18:77670439-77712536 (-)
BALB/cJ MGP_BALBcJ_G0024549
 protein coding gene Chr18:75635860-75677708 (-)
C3H/HeJ MGP_C3HHeJ_G0024318
 protein coding gene Chr18:77773820-77816968 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024996
 protein coding gene Chr18:80961635-81004664 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022426
 protein coding gene Chr18:74394628-74436832 (-)
CAST/EiJ MGP_CASTEiJ_G0023790
 protein coding gene Chr18:78104076-78145787 (-)
CBA/J MGP_CBAJ_G0024287
 protein coding gene Chr18:83863042-83912546 (-)
DBA/2J MGP_DBA2J_G0024417
 protein coding gene Chr18:74984731-75026977 (-)
FVB/NJ MGP_FVBNJ_G0024383
 protein coding gene Chr18:74347693-74391347 (-)
LP/J MGP_LPJ_G0024501
 protein coding gene Chr18:78790277-78836626 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024413
 protein coding gene Chr18:85072357-85117956 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025044
 protein coding gene Chr18:77850729-77894417 (-)
PWK/PhJ MGP_PWKPhJ_G0023535
 protein coding gene Chr18:75420413-75463850 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023339
 protein coding gene Chr18:78029789-78077277 (-)
WSB/EiJ MGP_WSBEiJ_G0023854
 protein coding gene Chr18:77797988-77842579 (-)



Homology
more
  • Human Ortholog
    SLC14A1, solute carrier family 14 member 1 (Kidd blood group)
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC14A1, solute carrier family 14 member 1 (Kidd blood group)
  • Synonyms
    HsT1341, HUT11, HUT11A, JK, Jk(a), Jk(b), RACH1, RACH2, UT1, UT-B1, UTE
  • Links
    NCBI Gene ID: 6563
    neXtProt AC: NX_Q13336
    UniProt: Q13336

  • Chr Location
    18q12.3; chr18:45687025-45752520 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 1 allele in 2 genetic backgrounds
    12 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display a grossly normal phenotype although they have an inability to concentrate urea in urine.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    998
  • Tissues
    207
  • cDNA Data
    39
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 108052 NCBI Gene Model | MGI Sequence Detail 42029 C57BL/6J ±  kb
    transcript NM_001171010 RefSeq | MGI Sequence Detail 3880 C57BL/6  
    polypeptide Q8VHL0 UniProt | EBI | MGI Sequence Detail 384 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 41
      cDNA 39
      Primer pair 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1917932, MGI:1919392
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 7
      Gene Ontology 7
      Phenotypes 15
    • Earliest
      J:59121 Fenton RA, et al., The murine urea transporter genes Slc14a1 and Slc14a2 occur in tandem on chromosome 18. Cytogenet Cell Genet. 1999;87(1-2):95-6
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory