About   Help   FAQ
Ptdss2 Gene Detail
Summary
  • Symbol
    Ptdss2
  • Name
    phosphatidylserine synthase 2
  • Synonyms
    PSS2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351664
    NCBI Gene: 27388
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:140711181-140736071 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 86.39 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    622 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351664
 protein coding gene Chr7:140702295-140737519 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033212
 protein coding gene Chr7:146293667-146329975 (+)
A/J MGP_AJ_G0033194
 protein coding gene Chr7:142111468-142147999 (+)
AKR/J MGP_AKRJ_G0033126
 protein coding gene Chr7:146027656-146062378 (+)
BALB/cJ MGP_BALBcJ_G0033195
 protein coding gene Chr7:141853013-141888315 (+)
C3H/HeJ MGP_C3HHeJ_G0032909
 protein coding gene Chr7:145778533-145818298 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033706
 protein coding gene Chr7:151644585-151681568 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030679
 protein coding gene Chr7:143322579-143356696 (+)
CAST/EiJ MGP_CASTEiJ_G0032239
 protein coding gene Chr7:138089432-138123163 (+)
CBA/J MGP_CBAJ_G0032881
 protein coding gene Chr7:156753720-156788191 (+)
DBA/2J MGP_DBA2J_G0033033
 protein coding gene Chr7:140060828-140095389 (+)
FVB/NJ MGP_FVBNJ_G0032986
 protein coding gene Chr7:139964248-140003195 (+)
LP/J MGP_LPJ_G0033128
 protein coding gene Chr7:147783485-147821246 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033019
 protein coding gene Chr7:157437926-157474024 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033726
 protein coding gene Chr7:145007415-145043979 (+)
PWK/PhJ MGP_PWKPhJ_G0031943
 protein coding gene Chr7:133337740-133373071 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031790
 protein coding gene Chr7:131820366-131859230 (+)
WSB/EiJ MGP_WSBEiJ_G0032350
 protein coding gene Chr7:145953561-145990999 (+)



Homology
more
  • Human Ortholog
    PTDSS2, phosphatidylserine synthase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PTDSS2, phosphatidylserine synthase 2
  • Synonyms
    PSS2
  • Links
    NCBI Gene ID: 81490
    neXtProt AC: NX_Q9BVG9
    UniProt: Q9BVG9

  • Chr Location
    11p15.5; chr11:448268-491399 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    3 phenotypes from multigenic genotypes
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Disruption of this gene causes infertility in about 10% of homozygous males. The remaining males and all females were fertile.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    857
  • Tissues
    115
  • cDNA Data
    22
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 27388 NCBI Gene Model | MGI Sequence Detail 24891 C57BL/6J ±  kb
    transcript NR_184743 RefSeq | MGI Sequence Detail 2179 C57BL/6  
    polypeptide Q9Z1X2 UniProt | EBI | MGI Sequence Detail 473 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 23
      cDNA 22
      Primer pair 1

      Microarray probesets 11
    Other
    Accession IDs
    less
    MGI:2141985, MGI:2142082
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 4
      Gene Ontology 6
      Phenotypes 19
    • Earliest
      J:57025 Stone SJ, et al., Cloning and expression of murine liver phosphatidylserine synthase (PSS)-2: differential regulation of phospholipid metabolism by PSS1 and PSS2. Biochem J. 1999 Aug 15;342(Pt 1):57-64
    • Latest
      J:190989 Kimura AK, et al., Phosphatidylserine synthase 2: high efficiency for synthesizing phosphatidylserine containing docosahexaenoic acid. J Lipid Res. 2013 Jan;54(1):214-22
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory