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Abca8b Gene Detail
Summary
  • Symbol
    Abca8b
  • Name
    ATP-binding cassette, sub-family A member 8b
  • Synonyms
    Abca8
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351668
    NCBI Gene: 27404
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:109823016-109886642 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 72.88 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1938 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351668
 protein coding gene Chr11:109823016-109886671 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019340
 protein coding gene Chr11:113520097-113590246 (-)
A/J MGP_AJ_G0019308
 protein coding gene Chr11:108623514-108687306 (-)
AKR/J MGP_AKRJ_G0019277
 protein coding gene Chr11:111876996-111945360 (-)
BALB/cJ MGP_BALBcJ_G0019282
 protein coding gene Chr11:109044215-109111769 (-)
C3H/HeJ MGP_C3HHeJ_G0019091
 protein coding gene Chr11:112165063-112232600 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019732
 protein coding gene Chr11:116948294-117023072 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017355
 protein coding gene Chr11:105819926-105881652 (-)
CAST/EiJ MGP_CASTEiJ_G0018644
 protein coding gene Chr11:113319198-113397208 (-)
CBA/J MGP_CBAJ_G0019060
 protein coding gene Chr11:121789439-121857081 (-)
DBA/2J MGP_DBA2J_G0019172
 protein coding gene Chr11:108085888-108152681 (-)
FVB/NJ MGP_FVBNJ_G0019163
 protein coding gene Chr11:107571028-107634602 (-)
LP/J MGP_LPJ_G0019242
 protein coding gene Chr11:113934065-114004982 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019194
 protein coding gene Chr11:120908704-120980264 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019769
 protein coding gene Chr11:112432969-112502940 (-)
PWK/PhJ MGP_PWKPhJ_G0018409
 protein coding gene Chr11:109255792-109322400 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018201
 protein coding gene Chr11:112250856-112314485 (-)
WSB/EiJ MGP_WSBEiJ_G0018696
 protein coding gene Chr11:112361598-112430103 (-)



Homology
more
  • Human Ortholog
    ABCA8, ATP binding cassette subfamily A member 8
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ABCA8, ATP binding cassette subfamily A member 8
  • Links
    NCBI Gene ID: 10351
    neXtProt AC: NX_O94911
    UniProt: O94911

  • Chr Location
    17q24.2; chr17:68867289-68955392 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased circulating HDL cholesterol levels on a high-cholesterol diet compared with wild-type mice.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    824
  • Tissues
    111
  • cDNA Data
    15
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 27404 NCBI Gene Model | MGI Sequence Detail 63627 C57BL/6J ±  kb
    transcript NM_001425480 RefSeq | MGI Sequence Detail 7434 C57BL/6  
    polypeptide Q8K440 UniProt | EBI | MGI Sequence Detail 1620 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 15
      Primer pair 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 3
      Gene Ontology 8
      Phenotypes 9
    • Earliest
      J:60841 Schriml LM, et al., Identification of 18 mouse ABC genes and characterization of the ABC superfamily in Mus musculus. Genomics. 2000 Feb 15;64(1):24-31
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory