Nr2f2 MGI Mouse Gene Detail - MGI:1352452 - nuclear receptor subfamily 2, group F, member 2

Symbol

Nr2f2
Name

nuclear receptor subfamily 2, group F, member 2
Synonyms

9430015G03Rik, Aporp1, ARP-1, COUP-TF2, COUP-TFII, EAR3, Tcfcoup2

Feature Type

protein coding gene
IDs

MGI:1352452
NCBI Gene: 11819
Alliance

gene page
Transcription Start Sites

27 TSS

Sequence Map

Chr7:70001692-70016483 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 38.66 cM
Mapping Data

7 experiments

SNPs within 2kb

197 from dbSNP Build 142
Strain Annotations

18
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1352452	protein coding gene	Chr7:70001692-70016494 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0032365	protein coding gene	Chr7:71780135-71797100 (-)
A/J	MGP_AJ_G0032344	protein coding gene	Chr7:70237879-70252667 (-)
AKR/J	MGP_AKRJ_G0032280	protein coding gene	Chr7:71709831-71724602 (-)
BALB/cJ	MGP_BALBcJ_G0032356	protein coding gene	Chr7:69971687-69986982 (-)
C3H/HeJ	MGP_C3HHeJ_G0032069	protein coding gene	Chr7:72428783-72443565 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0032848	protein coding gene	Chr7:74757477-74773358 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029856	protein coding gene	Chr7:72977047-72991913 (-)
CAST/EiJ	MGP_CASTEiJ_G0031397	protein coding gene	Chr7:63188284-63211873 (-)
CBA/J	MGP_CBAJ_G0032035	protein coding gene	Chr7:77137449-77154784 (-)
DBA/2J	MGP_DBA2J_G0032190	protein coding gene	Chr7:68913305-68928122 (-)
FVB/NJ	MGP_FVBNJ_G0032145	protein coding gene	Chr7:69016785-69031430 (-)
LP/J	MGP_LPJ_G0032271	protein coding gene	Chr7:72958885-72974520 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032182	protein coding gene	Chr7:77391594-77410914 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032866	protein coding gene	Chr7:71123253-71137915 (-)
PWK/PhJ	MGP_PWKPhJ_G0031117	protein coding gene	Chr7:62004188-62028498 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0030958	protein coding gene	Chr7:58119247-58144790 (-)
WSB/EiJ	MGP_WSBEiJ_G0031515	protein coding gene	Chr7:71468949-71484736 (-)

Human Ortholog

NR2F2, nuclear receptor subfamily 2 group F member 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NR2F2, nuclear receptor subfamily 2 group F member 2
Synonyms

ARP-1, ARP1, CHTD4, COUPTF2, COUPTFB, COUPTFII, NF-E3, SRXX5, SVP40, TFCOUP2
Links

HGNC:7976

NCBI Gene ID: 7026

neXtProt AC: NX_P24468

UniProt: P24468
Chr Location

15q26.2; chr15:96325938-96340263 (+) GRCh38

MGI Vertebrate Homology

Nr2f2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NR2F2
Gene Tree

Nr2f2

Diseases

2 with Nr2f2 mouse models; 1 with human NR2F2 associations

Human Disease

Mouse Models

congenital diaphragmatic hernia

IDs

View 1 model

dilated cardiomyopathy

IDs

View 1 model

46,XX sex reversal 5

IDs

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

2 with disease annotations

References

2 with disease annotations

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Phenotype Summary

83 phenotypes from 5 alleles in 9 genetic backgrounds
12 phenotypes from multigenic genotypes
69 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Chemically induced (other)

1
Endonuclease-mediated

1
Radiation induced

1
Targeted

9
Transgenic

1
Genomic Mutations

2 involving Nr2f2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

28 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for a targeted null mutation exhibit impaired angiogenesis and heart development with hemorrhagic brains and hearts, and die around embryonic day 10. About 5% of heterozygotes share the hemorrhagic phenotype at embryonic day 9.5.

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All GO Annotations

64
GO References

17

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1879
Tissues

566
cDNA Data

30
Literature Summary

184

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA NR2F2

Xenbase nr2f2

ZFIN nr2f2

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All Sequences

56
RefSeq

8
UniProt

4
CCDS

CCDS21358.1, CCDS21359.1

Ensembl

ENSMUSG00000030551 (Evidence)
NCBI Gene

11819

			Length	Strain/Species	Flank
genomic	ENSMUSG00000030551	Ensembl Gene Model \| MGI Sequence Detail	14792	C57BL/6J	± kb
transcript	ENSMUST00000032768	Ensembl \| MGI Sequence Detail	4222	Not Applicable
polypeptide	ENSMUSP00000032768	Ensembl \| MGI Sequence Detail	414	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000011405 COUP transcription factor 2

(term hierarchy)
InterPro Domains

IPR001723 Nuclear hormone receptor

IPR050274 Nuclear hormone receptor family NR2 subfamily

IPR000536 Nuclear hormone receptor, ligand-binding domain

IPR035500 Nuclear hormone receptor-like domain superfamily

IPR013088 Zinc finger, NHR/GATA-type

IPR001628 Zinc finger, nuclear hormone receptor-type
GlyGen

P43135 1 site, 1 O-linked glycan (1 site)

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All nucleic 57

Genomic 5

cDNA 33

Primer pair 11

Other 8

Microarray probesets 7

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MGD-MRK-18615, MGD-MRK-32408, MGI:101803, MGI:2444514

Summaries

All 278

Developmental Gene Expression 184

Diseases 2

Gene Ontology 17

Phenotypes 69
Earliest

J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
Latest

J:350469 Alderman PJ, et al., Delayed maturation and migration of excitatory neurons in the juvenile mouse paralaminar amygdala. Neuron. 2024 Feb 21;112(4):574-592.e10

TSS for Nr2f2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr72924	Chr7:70016790-70016799 (-)	-312 bp
Tssr72923	Chr7:70016484-70016519 (-)	-19 bp
Tssr72922	Chr7:70016265-70016312 (-)	194 bp
Tssr72921	Chr7:70016173-70016214 (-)	289 bp
Tssr72920	Chr7:70016096-70016164 (-)	353 bp
Tssr72919	Chr7:70015894-70015911 (-)	580 bp
Tssr72918	Chr7:70011545-70011558 (-)	4,931 bp
Tssr72917	Chr7:70011498-70011525 (-)	4,971 bp
Tssr72916	Chr7:70011471-70011496 (-)	4,999 bp
Tssr72915	Chr7:70011448-70011455 (-)	5,031 bp
Tssr72914	Chr7:70011382-70011432 (-)	5,076 bp
Tssr72913	Chr7:70011345-70011359 (-)	5,131 bp
Tssr72912	Chr7:70011326-70011331 (-)	5,154 bp
Tssr72911	Chr7:70011319-70011324 (-)	5,161 bp
Tssr72910	Chr7:70011276-70011297 (-)	5,196 bp
Tssr72909	Chr7:70011262-70011271 (-)	5,216 bp
Tssr72908	Chr7:70011203-70011212 (-)	5,275 bp
Tssr72907	Chr7:70011173-70011185 (-)	5,304 bp
Tssr72906	Chr7:70010479-70010494 (-)	5,996 bp
Tssr72905	Chr7:70009679-70009696 (-)	6,795 bp
Tssr72904	Chr7:70008765-70008791 (-)	7,705 bp
Tssr72903	Chr7:70007671-70007711 (-)	8,792 bp
Tssr72902	Chr7:70004426-70004464 (-)	12,038 bp
Tssr72901	Chr7:70004281-70004286 (-)	12,199 bp
Tssr2299	Chr7:70003950-70003967 (-)	12,524 bp
Tssr72900	Chr7:70003732-70003747 (-)	12,743 bp
Tssr72899	Chr7:70002665-70002670 (-)	13,815 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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