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Nr6a1 Gene Detail
Summary
  • Symbol
    Nr6a1
  • Name
    nuclear receptor subfamily 6, group A, member 1
  • Synonyms
    1700113M01Rik, Gcnf, NCNF
  • Feature Type
    protein coding gene
  • IDs
    MGI:1352459
    NCBI Gene: 14536
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:38613381-38816464 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 24.42 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3382 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1352459
 protein coding gene Chr2:38613381-38817700 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025705
 protein coding gene Chr2:37487945-37716130 (-)
A/J MGP_AJ_G0025682
 protein coding gene Chr2:35952068-36159559 (-)
AKR/J MGP_AKRJ_G0025652
 protein coding gene Chr2:37138100-37361976 (-)
BALB/cJ MGP_BALBcJ_G0025677
 protein coding gene Chr2:36001131-36227300 (-)
C3H/HeJ MGP_C3HHeJ_G0025438
 protein coding gene Chr2:37047593-37266756 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026123
 protein coding gene Chr2:38523741-38754160 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023528
 protein coding gene Chr2:34603130-34797470 (-)
CAST/EiJ MGP_CASTEiJ_G0024901
 protein coding gene Chr2:36999999-37219337 (-)
CBA/J MGP_CBAJ_G0025417
 protein coding gene Chr2:39965654-40208266 (-)
DBA/2J MGP_DBA2J_G0025549
 protein coding gene Chr2:35695635-35901213 (-)
FVB/NJ MGP_FVBNJ_G0025511
 protein coding gene Chr2:35562905-35766622 (-)
LP/J MGP_LPJ_G0025636
 protein coding gene Chr2:37370286-37590565 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025542
 protein coding gene Chr2:39568394-39802010 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026181
 protein coding gene Chr2:37022534-37248229 (-)
PWK/PhJ MGP_PWKPhJ_G0024643
 protein coding gene Chr2:35603616-35816928 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024448
 protein coding gene Chr2:37137803-37349192 (-)
WSB/EiJ MGP_WSBEiJ_G0024969
 protein coding gene Chr2:37198838-37419152 (-)



Homology
more
  • Human Ortholog
    NR6A1, nuclear receptor subfamily 6 group A member 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NR6A1, nuclear receptor subfamily 6 group A member 1
  • Synonyms
    CT150, GCNF, GCNF1, hGCNF, hRTR, NR61, RTR
  • Links
    NCBI Gene ID: 2649
    neXtProt AC: NX_Q15406
    UniProt: Q15406

  • Chr Location
    9q33.3; chr9:124517275-124771311 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    62 phenotypes from 7 alleles in 4 genetic backgrounds
    1 images
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations have cardiovascular abnormalities, defective trunk development, impaired somite formation, failure to turn, open neural tube and hindgut, protrusion of the tailbud outside the yolk sac and die by embryonic day 10.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1122
  • Tissues
    207
  • cDNA Data
    94
  • Literature Summary
    35
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14536 NCBI Gene Model | MGI Sequence Detail 203084 C57BL/6J ±  kb
    transcript NM_010264 RefSeq | MGI Sequence Detail 6143 C57BL/6  
    polypeptide Q64249 UniProt | EBI | MGI Sequence Detail 495 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000011413 nuclear receptor subfamily 6 group A member 1
      (term hierarchy)
    • PDB
      5KRB
    • InterPro Domains
      IPR001723 Nuclear hormone receptor
      IPR050200 Nuclear hormone receptor family NR3 subfamily
      IPR000536 Nuclear hormone receptor, ligand-binding domain
      IPR035500 Nuclear hormone receptor-like domain superfamily
      IPR013088 Zinc finger, NHR/GATA-type
      IPR001628 Zinc finger, nuclear hormone receptor-type
    Molecular
    Reagents
    less
    • All nucleic 106
      cDNA 96
      Primer pair 9
      Other 1

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-19678, MGI:102771, MGI:1923917
    References
    more
    • Summaries
      All 97
      Developmental Gene Expression 35
      Gene Ontology 13
      Phenotypes 27
    • Earliest
      J:21389 Chen F, et al., Cloning of a novel orphan receptor (GCNF) expressed during germ cell development. Mol Endocrinol. 1994 Oct;8(10):1434-44
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory