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Bcar3 Gene Detail
Summary
  • Symbol
    Bcar3
  • Name
    breast cancer anti-estrogen resistance 3
  • Synonyms
    AND-34
  • Feature Type
    protein coding gene
  • IDs
    MGI:1352501
    NCBI Gene: 29815
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:122213406-122323840 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 53.41 cM, cytoband G3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3465 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1352501
 protein coding gene Chr3:122087785-122323840 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027839
 protein coding gene Chr3:124553490-124806610 (+)
A/J MGP_AJ_G0027797
 protein coding gene Chr3:120384192-120624219 (+)
AKR/J MGP_AKRJ_G0027763
 protein coding gene Chr3:123449395-123694994 (+)
BALB/cJ MGP_BALBcJ_G0027809
 protein coding gene Chr3:120191862-120433344 (+)
C3H/HeJ MGP_C3HHeJ_G0027540
 protein coding gene Chr3:123847782-124094934 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028255
 protein coding gene Chr3:129210376-129325637 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025594
 protein coding gene Chr3:115809489-116050125 (+)
CAST/EiJ MGP_CASTEiJ_G0026996
 protein coding gene Chr3:123232537-123489459 (+)
CBA/J MGP_CBAJ_G0027515
 protein coding gene Chr3:133445506-133705293 (+)
DBA/2J MGP_DBA2J_G0027656
 protein coding gene Chr3:119519875-119759148 (+)
FVB/NJ MGP_FVBNJ_G0027624
 protein coding gene Chr3:117130850-117371715 (+)
LP/J MGP_LPJ_G0027766
 protein coding gene Chr3:126067781-126320604 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027654
 protein coding gene Chr3:141006825-141257263 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028311
 protein coding gene Chr3:123006649-123258467 (+)
PWK/PhJ MGP_PWKPhJ_G0026722
 protein coding gene Chr3:119220385-119468720 (+)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0027076
 protein coding gene Chr3:123734880-123985128 (+)



Homology
more
  • Human Ortholog
    BCAR3, BCAR3 adaptor protein, NSP family member
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BCAR3, BCAR3 adaptor protein, NSP family member
  • Synonyms
    AND-34, MIG7, NSP2, SH2D3B
  • Links
    NCBI Gene ID: 8412
    neXtProt AC: NX_O75815
    UniProt: O75815

  • Chr Location
    1p22.1; chr1:93561741-93848151 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 2 alleles in 3 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit cataracts due to rupture of the lens capsule and liquefaction of lens cortical fibers.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    781
  • Tissues
    22
  • cDNA Data
    57
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 29815 NCBI Gene Model | MGI Sequence Detail 110435 C57BL/6J ±  kb
    transcript NM_013867 RefSeq | MGI Sequence Detail 3332 C57BL/6  
    polypeptide Q9QZK2 UniProt | EBI | MGI Sequence Detail 820 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000004677 breast cancer anti-estrogen resistance protein 3
      (term hierarchy)
    • InterPro Domains
      IPR051853 Adapter protein with SH2 and Ras-GEF domains
      IPR036964 Ras guanine-nucleotide exchange factor, catalytic domain superfamily
      IPR023578 Ras guanine nucleotide exchange factor domain superfamily
      IPR001895 Ras guanine-nucleotide exchange factors catalytic domain
      IPR000980 SH2 domain
      IPR036860 SH2 domain superfamily
      IPR044102 SHEP1/BCAR3/NSP1, SH2 domain
    • GlyGen
      Q9QZK2 2 sites, 2 N-linked glycans (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 61
      cDNA 58
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2139634
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 10
      Phenotypes 17
    • Earliest
      J:56740 Cai D, et al., AND-34, a novel p130Cas-binding thymic stromal cell protein regulated by adhesion and inflammatory cytokines. J Immunol. 1999 Aug 15;163(4):2104-12
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory