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Scmh1 Gene Detail
Summary
  • Symbol
    Scmh1
  • Name
    sex comb on midleg homolog 1
  • Synonyms
    Scml3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1352762
    NCBI Gene: 29871
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:120262478-120387383 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 56.52 cM, cytoband D1-D2
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2260 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1352762
 protein coding gene Chr4:120262347-120387397 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028708
 protein coding gene Chr4:121658037-121788903 (+)
A/J MGP_AJ_G0028668
 protein coding gene Chr4:116868239-116995507 (+)
AKR/J MGP_AKRJ_G0028621
 protein coding gene Chr4:119417808-119556624 (+)
BALB/cJ MGP_BALBcJ_G0028691
 protein coding gene Chr4:117483599-117604010 (+)
C3H/HeJ MGP_C3HHeJ_G0028406
 protein coding gene Chr4:120967827-121093589 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029132
 protein coding gene Chr4:126240430-126381640 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026409
 protein coding gene Chr4:110955915-111067783 (+)
CAST/EiJ MGP_CASTEiJ_G0027837
 protein coding gene Chr4:118331865-118459423 (+)
CBA/J MGP_CBAJ_G0028373
 protein coding gene Chr4:129659730-129814411 (+)
DBA/2J MGP_DBA2J_G0028520
 protein coding gene Chr4:117456600-117575114 (+)
FVB/NJ MGP_FVBNJ_G0028486
 protein coding gene Chr4:115976687-116104261 (+)
LP/J MGP_LPJ_G0028620
 protein coding gene Chr4:121782424-121912096 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028514
 protein coding gene Chr4:134514696-134651986 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029169
 protein coding gene Chr4:120493086-120625131 (+)
PWK/PhJ MGP_PWKPhJ_G0027560
 protein coding gene Chr4:114395154-114520145 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027386
 protein coding gene Chr4:116928229-117062884 (+)
WSB/EiJ MGP_WSBEiJ_G0027917
 protein coding gene Chr4:120507203-120637493 (+)



Homology
more
  • Human Ortholog
    SCMH1, Scm polycomb group protein homolog 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SCMH1, Scm polycomb group protein homolog 1
  • Synonyms
    Scml3
  • Links
    NCBI Gene ID: 22955
    neXtProt AC: NX_Q96GD3
    UniProt: Q96GD3

  • Chr Location
    1p34.2; chr1:41027202-41242306 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    25 phenotypes from 3 alleles in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an allele lacking the SPM domain exhibit partial penetrance of posterior vertebral transformations and male infertility with azoospermia and arrest of spermatogenesis. Mice homozygous for a knock-out allele exhibit abnormal hematopoiesis but normal fertility and skeleton.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1022
  • Tissues
    245
  • cDNA Data
    23
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000000085 Ensembl Gene Model | MGI Sequence Detail 124906 C57BL/6J ±  kb
    transcript ENSMUST00000106301 Ensembl | MGI Sequence Detail 2584 Not Applicable  
    polypeptide ENSMUSP00000101908 Ensembl | MGI Sequence Detail 706 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 26
      Genomic 1
      cDNA 24
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2140226, MGI:2140390
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 11
      Gene Ontology 5
      Phenotypes 20
    • Earliest
      J:59388 Tomotsune D, et al., A novel member of murine Polycomb-group proteins, Sex comb on midleg homolog protein, is highly conserved, and interacts with RAE28/mph1 in vitro. Differentiation. 1999 Dec;65(4):229-39
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory