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Cbx8 Gene Detail
Summary
  • Symbol
    Cbx8
  • Name
    chromobox 8
  • Synonyms
    Pc3, polycomb 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353589
    NCBI Gene: 30951
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:118929262-118931739 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 83.33 cM, cytoband E2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    88 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1353589
 protein coding gene Chr11:118927131-118931795 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019473
 protein coding gene Chr11:123381385-123387610 (-)
A/J MGP_AJ_G0019441
 protein coding gene Chr11:117932544-117937208 (-)
AKR/J MGP_AKRJ_G0019411
 protein coding gene Chr11:121490405-121495069 (-)
BALB/cJ MGP_BALBcJ_G0019416
 protein coding gene Chr11:118291725-118296391 (-)
C3H/HeJ MGP_C3HHeJ_G0019222
 protein coding gene Chr11:121803275-121807972 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019865
 protein coding gene Chr11:127149302-127154923 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017490
 protein coding gene Chr11:114927870-114932548 (-)
CAST/EiJ MGP_CASTEiJ_G0018776
 protein coding gene Chr11:123249365-123255466 (-)
CBA/J MGP_CBAJ_G0019193
 protein coding gene Chr11:132085598-132093020 (-)
DBA/2J MGP_DBA2J_G0019305
 protein coding gene Chr11:117308818-117313489 (-)
FVB/NJ MGP_FVBNJ_G0019297
 protein coding gene Chr11:116966727-116972392 (-)
LP/J MGP_LPJ_G0019375
 protein coding gene Chr11:123706907-123711588 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019330
 protein coding gene Chr11:131052986-131058898 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019904
 protein coding gene Chr11:122159297-122163970 (-)
PWK/PhJ MGP_PWKPhJ_G0018542
 protein coding gene Chr11:118706884-118709988 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018334
 protein coding gene Chr11:121902548-121907193 (-)
WSB/EiJ MGP_WSBEiJ_G0018828
 protein coding gene Chr11:122127693-122132349 (-)



Homology
more
  • Human Ortholog
    CBX8, chromobox 8
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CBX8, chromobox 8
  • Synonyms
    PC3, RC1
  • Links
    NCBI Gene ID: 57332
    neXtProt AC: NX_Q9HC52
    UniProt: Q9HC52

  • Chr Location
    17q25.3; chr17:79792132-79801683 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired MLL-AF9 transformation but are otherwise viable with normal hematopoiesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    36
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    818
  • Tissues
    111
  • cDNA Data
    26
  • Literature Summary
    5
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 30951 NCBI Gene Model | MGI Sequence Detail 2478 C57BL/6J ±  kb
transcript NM_013926 RefSeq | MGI Sequence Detail 1413 Not Specified  
polypeptide Q9QXV1 UniProt | EBI | MGI Sequence Detail 362 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 28
    Genomic 1
    cDNA 27

    Microarray probesets 3
References
more
  • Summaries
    All 40
    Developmental Gene Expression 5
    Gene Ontology 10
    Phenotypes 6
  • Earliest
    J:60239 Hemenway CS, et al., Identification and analysis of a third mouse Polycomb gene, MPc3. Gene. 2000 Jan 25;242(1-2):31-40
  • Latest
    J:338403 Cho KW, et al., Polycomb Group Protein CBX7 Represses Cardiomyocyte Proliferation Through Modulation of the TARDBP/RBM38 Axis. Circulation. 2023 Jun 13;147(24):1823-1842
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory