About   Help   FAQ
Icosl Gene Detail
Summary
  • Symbol
    Icosl
  • Name
    icos ligand
  • Synonyms
    B7h, B7-H2, B7RP-1, GL50, GL50-B, ICOS-L, LICOS
  • Feature Type
    protein coding gene
  • IDs
    MGI:1354701
    NCBI Gene: 50723
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:77904921-77915359 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 39.72 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    282 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1354701
 protein coding gene Chr10:77904921-77919747 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017416
 protein coding gene Chr10:78491924-78502056 (+)
A/J MGP_AJ_G0017394
 protein coding gene Chr10:75764150-75774874 (+)
AKR/J MGP_AKRJ_G0017357
 protein coding gene Chr10:77789426-77802556 (+)
BALB/cJ MGP_BALBcJ_G0017356
 protein coding gene Chr10:75938872-75949049 (+)
C3H/HeJ MGP_C3HHeJ_G0017179
 protein coding gene Chr10:77877115-77887339 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017812
 protein coding gene Chr10:81270101-81280291 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015503
 protein coding gene Chr10:72111553-72121683 (+)
CAST/EiJ MGP_CASTEiJ_G0016749
 protein coding gene Chr10:78200838-78210988 (+)
CBA/J MGP_CBAJ_G0017151
 protein coding gene Chr10:84364131-84379370 (+)
DBA/2J MGP_DBA2J_G0017259
 protein coding gene Chr10:75004518-75014735 (+)
FVB/NJ MGP_FVBNJ_G0017251
 protein coding gene Chr10:74187780-74197950 (+)
LP/J MGP_LPJ_G0017330
 protein coding gene Chr10:78937506-78947680 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017278
 protein coding gene Chr10:86346851-86357019 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017854
 protein coding gene Chr10:77840117-77850247 (+)
PWK/PhJ MGP_PWKPhJ_G0016531
 protein coding gene Chr10:74881520-74891751 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016316
 protein coding gene Chr10:77056285-77066512 (+)
WSB/EiJ MGP_WSBEiJ_G0016809
 protein coding gene Chr10:77809818-77820029 (+)



Homology
more
  • Human Ortholog
    ICOSLG, inducible T cell costimulator ligand
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ICOSLG, inducible T cell costimulator ligand
  • Synonyms
    B7h, B7-H2, B7H2, B7RP-1, B7RP1, CD275, GL50, ICOS-L, ICOSL, IMD119, LICOS
  • Links
    NCBI Gene ID: 23308
    neXtProt AC: NX_O75144
    UniProt: O75144

  • Chr Location
    21q22.3; chr21:44215382-44241446 (-)  GRCh38
Human Diseases
less
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    27 phenotypes from 3 alleles in 3 genetic backgrounds
    82 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene exhibit defects in the humoral immune response associated with an impaired interactions between T and B cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    801
  • Tissues
    69
  • cDNA Data
    21
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 50723 NCBI Gene Model | MGI Sequence Detail 10439 C57BL/6J ±  kb
    transcript NM_015790 RefSeq | MGI Sequence Detail 2748 C57BL/6  
    polypeptide Q9JHJ8 UniProt | EBI | MGI Sequence Detail 322 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 23
      cDNA 21
      Primer pair 1
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2143770, MGI:2652130
    References
    more
    • Summaries
      All 134
      Developmental Gene Expression 3
      Diseases 2
      Gene Ontology 7
      Phenotypes 82
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:357279 Donovan MG, et al., Multimodal analysis of dysregulated heme metabolism, hypoxic signaling, and stress erythropoiesis in Down syndrome. Cell Rep. 2024 Aug 27;43(8):114599
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory