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Kdm2b Gene Detail
Summary
  • Symbol
    Kdm2b
  • Name
    lysine (K)-specific demethylase 2B
  • Synonyms
    Cxxc2, Fbxl10, Jhdm1b, mKIAA3014
  • Feature Type
    protein coding gene
  • IDs
    MGI:1354737
    NCBI Gene: 30841
  • Alliance
    gene page
  • Transcription Start Sites
    25 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:123008727-123127333 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 62.63 cM, cytoband F
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    3465 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1354737
 protein coding gene Chr5:123008727-123127886 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030060
 protein coding gene Chr5:126547407-126668553 (-)
A/J MGP_AJ_G0030025
 protein coding gene Chr5:121290357-121409821 (-)
AKR/J MGP_AKRJ_G0029961
 protein coding gene Chr5:125200743-125327257 (-)
BALB/cJ MGP_BALBcJ_G0030036
 protein coding gene Chr5:122637687-122757782 (-)
C3H/HeJ MGP_C3HHeJ_G0029753
 protein coding gene Chr5:125822315-125949426 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030489
 protein coding gene Chr5:131415000-131547475 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027715
 protein coding gene Chr5:115892105-116011065 (-)
CAST/EiJ MGP_CASTEiJ_G0029162
 protein coding gene Chr5:124918872-125048359 (-)
CBA/J MGP_CBAJ_G0029723
 protein coding gene Chr5:136564245-136702914 (-)
DBA/2J MGP_DBA2J_G0029873
 protein coding gene Chr5:121347370-121469461 (-)
FVB/NJ MGP_FVBNJ_G0029829
 protein coding gene Chr5:120345811-120469074 (-)
LP/J MGP_LPJ_G0029962
 protein coding gene Chr5:127079729-127204927 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029860
 protein coding gene Chr5:140251957-140383052 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030530
 protein coding gene Chr5:124800251-124926777 (-)
PWK/PhJ MGP_PWKPhJ_G0028876
 protein coding gene Chr5:120132631-120255862 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028713
 protein coding gene Chr5:122502451-122620015 (-)
WSB/EiJ MGP_WSBEiJ_G0029237
 protein coding gene Chr5:125467503-125594816 (-)



Homology
more
  • Human Ortholog
    KDM2B, lysine demethylase 2B
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KDM2B, lysine demethylase 2B
  • Synonyms
    CXXC2, Fbl10, FBXL10, JHDM1B, PCCX2
  • Links
    NCBI Gene ID: 84678
    neXtProt AC: NX_Q8NHM5
    UniProt: Q8NHM5

  • Chr Location
    12q24.31; chr12:121408461-121582279 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 2 alleles in 2 genetic backgrounds
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted allele that does not express the long form protein exhibit exencephaly, fetal and postnatal lethality, coloboma, curly tail, oligozoospermia, increased apoptosis, and increased neuronal precursor proliferation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    43
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    786
  • Tissues
    35
  • cDNA Data
    17
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 30841 NCBI Gene Model | MGI Sequence Detail 118607 C57BL/6J ±  kb
    transcript NM_001003953 RefSeq | MGI Sequence Detail 5191 C57BL/6  
    polypeptide Q6P1G2 UniProt | EBI | MGI Sequence Detail 1309 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 17
      Primer pair 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 83
      Developmental Gene Expression 13
      Gene Ontology 13
      Phenotypes 28
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:341689 Zhang B, et al., KDM2B regulates hippocampal morphogenesis by transcriptionally silencing Wnt signaling in neural progenitors. Nat Commun. 2023 Oct 14;14(1):6489
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    11/19/2024
    MGI 6.24     		The Jackson Laboratory