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Klf13 Gene Detail
Summary
  • Symbol
    Klf13
  • Name
    Kruppel-like transcription factor 13
  • Synonyms
    9430029L20Rik, Bteb3, FKLF-2, Klf13, NSLP1, RFLAT-1, RFLAT1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1354948
    NCBI Gene: 50794
  • Alliance
    gene page
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:63536099-63588663 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 34.58 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1378 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1354948
 protein coding gene Chr7:63536099-63588663 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032332
 protein coding gene Chr7:65000460-65057040 (-)
A/J MGP_AJ_G0032311
 protein coding gene Chr7:63758650-63813652 (-)
AKR/J MGP_AKRJ_G0032247
 protein coding gene Chr7:65106593-65158271 (-)
BALB/cJ MGP_BALBcJ_G0032323
 protein coding gene Chr7:63498267-63551480 (-)
C3H/HeJ MGP_C3HHeJ_G0032036
 protein coding gene Chr7:65741076-65807057 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032816
 protein coding gene Chr7:67781872-67842988 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029823
 protein coding gene Chr7:66719175-66771250 (-)
CAST/EiJ MGP_CASTEiJ_G0031365
 protein coding gene Chr7:56414903-56475370 (-)
CBA/J MGP_CBAJ_G0032002
 protein coding gene Chr7:69971751-70046883 (-)
DBA/2J MGP_DBA2J_G0032158
 protein coding gene Chr7:62489485-62550145 (-)
FVB/NJ MGP_FVBNJ_G0032112
 protein coding gene Chr7:62593275-62650889 (-)
LP/J MGP_LPJ_G0032238
 protein coding gene Chr7:66225765-66293543 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032149
 protein coding gene Chr7:70278404-70335089 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032833
 protein coding gene Chr7:64365621-64425623 (-)
PWK/PhJ MGP_PWKPhJ_G0031085
 protein coding gene Chr7:55502979-55557323 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030926
 protein coding gene Chr7:51509213-51566185 (-)
WSB/EiJ MGP_WSBEiJ_G0031483
 protein coding gene Chr7:64751786-64813138 (-)



Homology
more
  • Human Ortholog
    KLF13, KLF transcription factor 13
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KLF13, KLF transcription factor 13
  • Synonyms
    BTEB3, FKLF2, NSLP1, RFLAT-1, RFLAT1
  • Links
    NCBI Gene ID: 51621
    neXtProt AC: NX_Q9Y2Y9
    UniProt: Q9Y2Y9

  • Chr Location
    15q13.3; chr15:31326835-31435665 (+)  GRCh38
Human Diseases
less
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 2 alleles in 2 genetic backgrounds
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a disruption in this gene are grossly normal. Prolonged thymocyte survival leads to an enlarged thymus and spleen. Mice homozygous for a different allele exhibit splenomegaly and abnormal erythropoiesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    905
  • Tissues
    171
  • cDNA Data
    107
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 50794 NCBI Gene Model | MGI Sequence Detail 52565 C57BL/6J ±  kb
    transcript NM_021366 RefSeq | MGI Sequence Detail 6396 C57BL/6  
    polypeptide Q9JJZ6 UniProt | EBI | MGI Sequence Detail 289 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 113
      cDNA 110
      Primer pair 3

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1915649, MGI:1924575
    References
    more
    • Summaries
      All 76
      Developmental Gene Expression 10
      Diseases 2
      Gene Ontology 9
      Phenotypes 29
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:348102 Unda BK, et al., Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome. Mol Psychiatry. 2023 Apr;28(4):1747-1769
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory